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Titolo:
Evidence for a role of GABA interneurones in the cortical modulation of midbrain 5-hydroxytryptamine neurones
Autore:
Varga, V; Szekely, AD; Csillag, A; Sharp, T; Hajos, M;
Indirizzi:
Univ Oxford, Dept Pharmacol, Oxford OX2 6HE, England Univ Oxford Oxford England OX2 6HE pt Pharmacol, Oxford OX2 6HE, England Semmelweis Univ Med, Dept Anat, H-1450 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1450 at, H-1450 Budapest, Hungary Natl Inst Neurosurg, Budapest, Hungary Natl Inst Neurosurg Budapest Hungary Inst Neurosurg, Budapest, Hungary
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 106, anno: 2001,
pagine: 783 - 792
SICI:
0306-4522(2001)106:4<783:EFAROG>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL RAPHE NUCLEUS; MEDIAL PREFRONTAL CORTEX; GAMMA-AMINOBUTYRIC ACID; SEROTONERGIC NEURONS; EFFERENT PROJECTIONS; GABAERGIC NEURONS; IMMUNOCYTOCHEMICAL TECHNIQUES; PONTOMESENCEPHALIC TEGMENTUM; RAT; INNERVATION;
Keywords:
medial prefrontal cortex; dorsal raphe nucleus; GABA; 5-HT; electron microscopy; electrophysiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Sharp, T Univ Oxford, Dept Pharmacol, S Parks Rd, Oxford OX2 6HE, England Univ Oxford S Parks Rd Oxford England OX2 6HE d OX2 6HE, England
Citazione:
V. Varga et al., "Evidence for a role of GABA interneurones in the cortical modulation of midbrain 5-hydroxytryptamine neurones", NEUROSCIENC, 106(4), 2001, pp. 783-792

Abstract

Recent electrophysiological studies demonstrate that the ventral medial prefrontal cortex has a powerful inhibitory influence on 5-hydroxytryptamine (5-HT) neurones in the dorsal raphe nucleus. Here we utilised a combinationof anatomical and electrophysiological methods to characterise the cellular substrate underlying this effect. Anterograde tracing (Phaseolus vulgaris leucoagglutinin) using electron microscopy demonstrated a pathway from the ventral medial prefrontal cortex that makes neuronal contacts throughout the dorsal raphe nucleus. These contacts were predominantly asymmetrical synapses adjoining GABA immunoreactivedendrites and spines. In vivo extracellular recordings were made in the dorsal raphe nucleus of the anaesthetised rat from a subpopulation of non-5-HT neurones. These neurones were fast-firing, irregular and with short spike width, properties strongly reminiscent of immunochemically identified GABA interneurones. in other brain regions. Recordings of classical 5-HT neurones were also included. Electrical stimulation of the ventral medial prefrontal cortex elicited a rapid onset (16 ms latency), orthodromic excitation of the non-5-HT neurones (13/25 neurones). This stimulation also caused a pronounced inhibition ofmost 5-HT neurones tested, with a longer latency (30 ins), and this was partially blocked by locally applied bicuculline. These data provide the first evidence that the ventral medial prefrontal. cortex influences the activity of large numbers of raphe 5-HT neurones by targeting a local network of GABA neurones. This circuitry predicts that physiological and pathological changes in the ventral medial prefrontal cortexwill impact on significant parts of the forebrain 5-HT system. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

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Documento generato il 29/03/20 alle ore 12:15:53