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Titolo:
Differential and age-dependent expression of hyperpolarization-activated, cyclic nucleotide-gated cation channel isoforms 1-4 suggests evolving rolesin the developing rat hippocampus
Autore:
Bender, RA; Brewster, A; Santoro, B; Ludwig, A; Hofmann, F; Biel, M; Baram, TZ;
Indirizzi:
Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 t & Neurobiol, Irvine, CA 92697 USA Univ Calif Irvine, Dept Pediat, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 , Dept Pediat, Irvine, CA 92697 USA Columbia Univ, Ctr Neurobiol & Behav, Columbia, NY USA Columbia Univ Columbia NY USA v, Ctr Neurobiol & Behav, Columbia, NY USA Tech Univ Munich, Inst Pharmacol & Toxicol, D-8000 Munich, Germany Tech Univ Munich Munich Germany D-8000 & Toxicol, D-8000 Munich, Germany Univ Munich, Zentrum Pharmaforsch, Munich, Germany Univ Munich Munich Germany unich, Zentrum Pharmaforsch, Munich, Germany
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 106, anno: 2001,
pagine: 689 - 698
SICI:
0306-4522(2001)106:4<689:DAAEOH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PACEMAKER CHANNELS; LONG-TERM; MOLECULAR CHARACTERIZATION; NETWORK OSCILLATIONS; NEONATAL HIPPOCAMPUS; NEURONAL POPULATIONS; STRATUM-ORIENS; GENE FAMILY; AREA CA3; INTERNEURONS;
Keywords:
development; pacemaker; ion channel; synchronization; interneurons; plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Baram, TZ Univ Calif Irvine, Dept Anat & Neurobiol, ZOT 4475, Irvine, CA 92697 USA Univ Calif Irvine ZOT 4475 Irvine CA USA 92697 ine, CA 92697 USA
Citazione:
R.A. Bender et al., "Differential and age-dependent expression of hyperpolarization-activated, cyclic nucleotide-gated cation channel isoforms 1-4 suggests evolving rolesin the developing rat hippocampus", NEUROSCIENC, 106(4), 2001, pp. 689-698

Abstract

Hyperpolarization-activated cation currents (I-h) are found in several brain regions including thalamus and hippocampus. Important functions of thesecurrents in promoting synchronized network activity and in determining neuronal membrane properties have been progressively recognized, but the molecular underpinnings of these currents are only emerging. I-h currents are generated by hyperpolarization-activated, cyclic nucleotide-gated cation channels (HCNs). These channel proteins are encoded by at least four HCN genes,that govern the kinetic and functional properties of the resulting channels. Because of the potential impact of I-h-mediated coordinated neuronal activity on the maturation of the functional hippocampal network, this study focused on determining the expression of the four members of the HCN gene family throughout postnatal hippocampal development at both the regional and single cell level. The results of these experiments demonstrated that HCNs 1, 2 and 4 are differentially expressed in interneuronal and principal cell populations of the rat hippocampal formation. Expression profiles of each HCN isoform evolveduring postnatal development, and patterns observed during early postnatalages differ significantly from those in mature hippocampus. The onset of HCN expression in interneurons of the hippocampus proper precedes that in the dentate gyrus, suggesting that HCN-mediated pacing activity may be generated in hippocampal interneurons prior to those in the hilus. Taken together, these findings indicate an age-dependent spatiotemporal evolution of specific HCN expression in distinct hippocampal cell populations, and suggest that these channels serve differing and evolving functions inthe maturation of coordinated hippocampal activity. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:12:50