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Titolo:
A critical role of a facilitatory presynaptic kainate receptor in mossy fiber LTP
Autore:
Lauri, SE; Bortolotto, ZA; Bleakman, D; Ornstein, PL; Lodge, D; Isaac, JTR; Collingridge, GL;
Indirizzi:
Univ Bristol, Sch Med, Dept Anat, MRC,Ctr Synapt Plast, Bristol BS8 1TD, Avon, England Univ Bristol Bristol Avon England BS8 1TD Bristol BS8 1TD, Avon, England Eli Lilly & Co, Lilly Corp Ctr, Indianapolis, IN 46285 USA Eli Lilly & CoIndianapolis IN USA 46285 Ctr, Indianapolis, IN 46285 USA
Titolo Testata:
NEURON
fascicolo: 4, volume: 32, anno: 2001,
pagine: 697 - 709
SICI:
0896-6273(20011120)32:4<697:ACROAF>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; HIPPOCAMPAL CA3 NEURONS; SYNAPTIC ACTIVATION; RAT HIPPOCAMPUS; BINDING-SITES; GLUR5 SUBTYPE; 2 FORMS; PLASTICITY; SYNAPSES; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Collingridge, GL Univ Bristol, Sch Med, Dept Anat, MRC,Ctr Synapt Plast, Bristol BS8 1TD, Avon, England Univ Bristol Bristol Avon England BS8 1TD Avon, England
Citazione:
S.E. Lauri et al., "A critical role of a facilitatory presynaptic kainate receptor in mossy fiber LTP", NEURON, 32(4), 2001, pp. 697-709

Abstract

The mechanisms involved in mossy fiber LTP in the hippocampus are not wellestablished. In the present study, we show that the kainate receptor antagonist LY382884 (10 muM) is selective for presynaptic kainate receptors in the CA3 region of the hippocampus. At a concentration at which it blocks mossy fiber LTP, LY382884 selectively blocks the synaptic activation of a presynaptic kainate receptor that facilitates AMPA receptor-mediated synaptic transmission. Following the induction of mossy fiber LTP, there is a complete loss of the presynaptic kainate receptor-mediated facilitation of synaptic transmission. These results identify a central role for the presynaptic kainate receptor in the induction of mossy fiber LTP. In addition, these results suggest that the pathway by which kainate receptors facilitate glutamate release is utilized for the expression of mossy fiber LTP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:04:32