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Titolo:
Inactivity produces increases in neurotransmitter release and synapse size
Autore:
Murthy, VN; Schikorski, T; Stevens, CF; Zhu, YL;
Indirizzi:
Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA Harvard Univ Cambridge MA USA 02138 ellular Biol, Cambridge, MA 02138 USA Salk Inst Biol Studies, Howard Hughes Med Inst, La Jolla, CA 92037 USA Salk Inst Biol Studies La Jolla CA USA 92037 Inst, La Jolla, CA 92037 USA Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USA Salk Inst Biol Studies La Jolla CA USA 92037 Lab, La Jolla, CA 92037 USA
Titolo Testata:
NEURON
fascicolo: 4, volume: 32, anno: 2001,
pagine: 673 - 682
SICI:
0896-6273(20011120)32:4<673:IPIINR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
BARREL FIELD CORTEX; HIPPOCAMPAL SYNAPSES; DENDRITIC SPINES; QUANTAL ANALYSIS; RAT HIPPOCAMPUS; PYRAMIDAL CELLS; NEURONS; RECEPTOR; AMPA; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Stevens, CF Harvard Univ, Dept Mol & Cellular Biol, 16 Divin Ave, Cambridge, MA 02138 USA Harvard Univ 16 Divin Ave Cambridge MA USA 02138 MA 02138 USA
Citazione:
V.N. Murthy et al., "Inactivity produces increases in neurotransmitter release and synapse size", NEURON, 32(4), 2001, pp. 673-682

Abstract

When hippocampal synapses in culture are pharmacologically silenced for several days, synaptic strength increases. The structural correlate of this change in strength is an increase in the size of the synapses, with all synaptic components-active zone, postsynaptic density, and bouton-becoming larger. Further, the number of docked vesicles and the total number of vesiclesper synapse increases, although the number of docked vesicles per area of active zone is unchanged. In parallel with these anatomical changes, the physiologically measured size of the readily releasable pool (RRP) and the release probability are increased. Ultrastructural analysis of individual synapses in which the RRP was previously measured reveals that, within measurement error, the same number of vesicles are docked as are estimated to be in the RRP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 02:37:47