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Titolo:
Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway
Autore:
Monuki, ES; Porter, FD; Walsh, CA;
Indirizzi:
Beth Israel Deaconess Med Ctr, Div Neurogenet, Boston, MA 02115 USA Beth Israel Deaconess Med Ctr Boston MA USA 02115 t, Boston, MA 02115 USA Childrens Hosp, Dept Pathol, Div Neuropathol, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 Div Neuropathol, Boston, MA 02115 USA Brigham & Womens Hosp, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 mens Hosp, Boston, MA 02115 USA NICHHD, Heritable Disorders Branch, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892 isorders Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
NEURON
fascicolo: 4, volume: 32, anno: 2001,
pagine: 591 - 604
SICI:
0896-6273(20011120)32:4<591:POTDTA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; IN-SITU HYBRIDIZATION; PROMOTER DIRECTS EXPRESSION; REGULATORY GENES; TRANSGENIC MICE; NEURAL CREST; FOREBRAIN DEVELOPMENT; CORTICAL-NEURONS; SPINAL-CORD; DLX GENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Walsh, CA Univ Calif Irvine, Coll Med, Dept Pathol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 hol, Irvine, CA 92697 USA
Citazione:
E.S. Monuki et al., "Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway", NEURON, 32(4), 2001, pp. 591-604

Abstract

The organizing centers and molecules that pattern the cerebral cortex havebeen elusive. Here we show that cortical patterning involves regulation ofthe Lhx2 homeobox gene by the roof plate. Roof plate ablation results in reduced cortical size and Lhx2 expression defects that implicate roof plate signals in the bimodal regulation of Lhx2 in vivo. Bimodal Lhx2 regulation can be recapitulated in explants using two roof plate-derived signaling molecules, Bmp4 and Bmp2. Loss of Lhx2 function results in profound losses of cortical progenitors and neurons, but Lhx2 mutants continue to generate cortical neurons from dorsal sources that may include the roof plate region itself. These findings provide evidence for the roof plate as an organizing center of the developing cortex and for a roof plate-Lhx2 pathway in cortical patterning.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:09:59