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Titolo:
Genome-wide linkage disequilibrium mapping of late-onset Alzheimer's disease in Finland
Autore:
Hiltunen, M; Mannermaa, A; Thompson, D; Easton, D; Pirskanen, M; Helisalmi, S; Koivisto, AM; Lehtovirta, M; Ryynanen, M; Soininen, H;
Indirizzi:
Kuopio Univ Hosp, Dept Clin Genet, FIN-70211 Kuopio, Finland Kuopio Univ Hosp Kuopio Finland FIN-70211 net, FIN-70211 Kuopio, Finland Kuopio Univ Hosp, Dept Neurol, FIN-70211 Kuopio, Finland Kuopio Univ HospKuopio Finland FIN-70211 rol, FIN-70211 Kuopio, Finland Univ Kuopio, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 v Kuopio, FIN-70211 Kuopio, Finland Oulu Univ Hosp, Dept Obstet & Gynaecol, Oulu, Finland Oulu Univ Hosp Oulu Finland Hosp, Dept Obstet & Gynaecol, Oulu, Finland Univ Cambridge, Strangeways Res Lab, CRC, Genet Epidemiol Grp, Cambridge CB2 1TN, England Univ Cambridge Cambridge England CB2 1TN Grp, Cambridge CB2 1TN, England
Titolo Testata:
NEUROLOGY
fascicolo: 9, volume: 57, anno: 2001,
pagine: 1663 - 1668
SICI:
0028-3878(20011113)57:9<1663:GLDMOL>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-E; MISSENSE MUTATIONS; COMPLEX DISEASES; E GENOTYPE; GENE; CHROMOSOME-12; POPULATION; ALLELE; LOCUS; EPSILON-4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Hiltunen, M Kuopio Univ Hosp, Dept Clin Genet, POB 1777, FIN-70211 Kuopio,Finland Kuopio Univ Hosp POB 1777 Kuopio Finland FIN-70211 o, Finland
Citazione:
M. Hiltunen et al., "Genome-wide linkage disequilibrium mapping of late-onset Alzheimer's disease in Finland", NEUROLOGY, 57(9), 2001, pp. 1663-1668

Abstract

Background: AD is a complex neurodegenerative disorder comprising several disease-associated chromosome loci. To find novel susceptibility genes for late-onset AD, a population-based genome-wide search using linkage disequilibrium (LD) mapping approach has been performed. Methods: Forty-seven patients with late-onset AD and 51 age-matched control subjects were carefully chosen from the same geographic area in eastern Finland, where the population is descended mainly from a small group of original founders. These subjects were initially genotyped with 366 polymorphic microsatellite markers, and a follow-up analysis was performed with additional microsatellite markersfor those chromosome loci found to be associated with AD. Results: Initialgenome-wide screening revealed 21 chromosomal loci significantly associated with AD in addition to the 13q12 locus described previously. Subsequent comparison of single-allele frequencies of the microsatellite markers in theAD and control groups indicated the presence both of possible risk alleles(odds ratio [OR] > 1) and of possible protective alleles (OR < 1). Screening of the LD regions with additional microsatellite markers revealed seven chromosomal loci where more than one microsatellite marker was associated with AD (1p36.12, 2p22.2, 3q28, 4p13, 10p13, 18q12.1, and 19p13.3) in addition to the 13q12 locus. Conclusions: These genome-wide LD screening data suggest that several AD-associated chromosomal loci exist, which may encompassnovel susceptibility genes for late-onset AD. Therefore, extensive screening of the genes located in the vicinity of these LD regions is necessary toelucidate their role in AD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:57:48