Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Diffusion-perfusion MR evaluation of perihematomal injury in hyperacute intracerebral hemorrhage
Autore:
Kidwell, CS; Saver, JL; Mattiello, J; Warach, S; Liebeskind, DS; Starkman, S; Vespa, PM; Villablanca, JP; Martin, NA; Frazee, J; Alger, JR;
Indirizzi:
Univ Calif Los Angeles, Med Ctr, Stroke Ctr, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Med Ctr, Dept Neurol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Med Ctr, Dept Radiol Sci, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Med Ctr, Dept Emergency Med, Los Angeles, CA 90095USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095USA Univ Calif Los Angeles, Med Ctr, Dept Neurosurg, Los Angeles, CA 90095 USAUniv Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA NINCDS, Stroke Branch, NIH, Bethesda, MD 20892 USA NINCDS Bethesda MD USA20892 , Stroke Branch, NIH, Bethesda, MD 20892 USA Univ Penn, Comprehens Stroke Ctr, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 troke Ctr, Philadelphia, PA 19104 USA Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA Univ Penn PhiladelphiaPA USA 19104 pt Neurol, Philadelphia, PA 19104 USA
Titolo Testata:
NEUROLOGY
fascicolo: 9, volume: 57, anno: 2001,
pagine: 1611 - 1617
SICI:
0028-3878(20011113)57:9<1611:DMEOPI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; HIGH-RESOLUTION MEASUREMENT; BRAIN-BARRIER PERMEABILITY; SPONTANEOUS MASS LESION; TRACER BOLUS PASSAGES; WEIGHTED MRI; ISCHEMIC PENUMBRA; EDEMA FORMATION; ACUTE STROKE; SURGERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Kidwell, CS Univ Calif Los Angeles, Med Ctr, Stroke Ctr, 710 Westwood Plaza, Los Angeles, CA 90095 USA Univ Calif Los Angeles 710 Westwood Plaza Los Angeles CA USA 90095
Citazione:
C.S. Kidwell et al., "Diffusion-perfusion MR evaluation of perihematomal injury in hyperacute intracerebral hemorrhage", NEUROLOGY, 57(9), 2001, pp. 1611-1617

Abstract

Background: It has been suggested that a zone of perihematomal ischemia analogous to an ischemic penumbra exists in patients with primary intracerebral hemorrhage (ICH). Diffusion-perfusion MRI provides a novel means of assessing injury in perihematomal regions in patients with ICH. Objective: To characterize diffusion-perfusion MRI changes in the perihematomal region in patients with hyperacute intracerebral hemorrhage. Methods: Twelve patientspresenting with hyperacute, primary ICH undergoing CT scanning and diffusion-perfusion MRI within 6 hours of symptom onset were reviewed. An automated thresholding technique was used to identify decreased apparent diffusion coefficient (ADC) values in the perihematomal regions. Perfusion maps were examined for regions of relative hypo- or hyperperfusion. Results: Median baseline NIH Stroke Scale score was 17 (range, 6 to 28). Median hematoma volume was 13.3 mL (range, 3.0 to 74.8 mL). MRI detected the hematoma in all patients on echo-planar susceptibility-weighted imaging and in all seven patients imaged with gradient echo sequences. In six patients who underwent perfusion imaging, no focal defects were visualized on perfusion maps in tissues adjacent to the hematoma; however, five of six patients demonstrated diffuse ipsilateral hemispheric hypoperfusion. On diffusion imaging, perihematomal regions of decreased ADC values were identified in three of 12 patients. All three subsequently showed clinical and radiologic deterioration. Conclusions: A rim of perihematomal decreased ADC values was visualized in the hyperacute period in a subset of patients with ICH. The presence of a rimof decreased ADC outside the hematoma correlated with poor clinical outcome. Although perfusion maps did not demonstrate a focal zone of perihematomal decreased blood flow in any patient, most patients had ipsilateral hemispheric hypoperfusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:47:45