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Titolo:
Volumetric analysis reveals corticospinal tract degeneration and extramotor involvement in ALS
Autore:
Ellis, CM; Suckling, J; Amaro, E; Bullmore, ET; Simmons, A; Williams, SCR; Leigh, PN;
Indirizzi:
Inst Psychiat, Dept Clin Neurosci, Brain Image Anal Unit, London SE5 8AF, England Inst Psychiat London England SE5 8AF Anal Unit, London SE5 8AF, England Guys Kings & St Thomas Sch Med & Dent, Dept Neurol, London, England Guys Kings & St Thomas Sch Med & Dent London England l, London, England Guys Kings & St Thomas Sch Med & Dent, Clin Age Res Unit, London, England Guys Kings & St Thomas Sch Med & Dent London England t, London, England Univ Cambridge, Addenbrookes Hosp, Dept Psychiat, Cambridge CB2 2QQ, England Univ Cambridge Cambridge England CB2 2QQ iat, Cambridge CB2 2QQ, England Maudsley Hosp & Inst Psychiat, Dept Neuroimaging, London SE5 8AZ, England Maudsley Hosp & Inst Psychiat London England SE5 8AZ on SE5 8AZ, England
Titolo Testata:
NEUROLOGY
fascicolo: 9, volume: 57, anno: 2001,
pagine: 1571 - 1578
SICI:
0028-3878(20011113)57:9<1571:VARCTD>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; POSITRON EMISSION TOMOGRAPHY; MOTOR-NEURON DISEASE; MAGNETIC-RESONANCE SPECTROSCOPY; MULTISYSTEM DEGENERATION; CORTICAL FUNCTION; WHITE MATTER; SPINAL-CORD; MR-IMAGES; CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Ellis, CM Inst Psychiat, Dept Clin Neurosci, Brain Image Anal Unit, De Crespigny Pk,London SE5 8AF, England Inst Psychiat De Crespigny Pk London England SE5 8AF F, England
Citazione:
C.M. Ellis et al., "Volumetric analysis reveals corticospinal tract degeneration and extramotor involvement in ALS", NEUROLOGY, 57(9), 2001, pp. 1571-1578

Abstract

Background: Pathologic changes in the motor cortex and corticospinal tracts in ALS may be reflected by abnormal signal intensities on conventional MRI. The sensitivity of these changes in detecting underlying pathology remains unclear. Methods: The authors used automated image analysis to quantify volumes of cerebral gray and white matter in 16 patients with ALS (eight limb onset, eight bulbar onset) and eight normal controls. Previously they had demonstrated a reduction in N-acetyl aspartate/creatine + phosphocreatine(NAA/[Cr + PCr]) measured by H-1-MRS in the subcortical white matter in the motor cortex region in the patients with bulbar-onset ALS. To determine whether this resulted from axonal degeneration, they also compared gray and white matter volumes in the patients with limb- and bulbar-onset ALS. Results: There were no differences in the total brain volumes of gray or white matter for the three subject groups (p > 0.23). Comparison of the total ALS group and controls revealed localized deficits in gray matter volume centered on Brodmann areas 8, 9, and 10 bilaterally. Comparison of the patients with limb- and bulbar-onset ALS revealed deficits in the white matter volumein the bulbar-onset group, extending bilaterally from the precentral gyrosinto the internal capsule and brainstem, consistent with the course of thecorticospinal tract. There was no loss in gray matter volume in the precentral gyri, Conclusions: The loss of gray matter in the frontal regions (total ALS group) provides further support that ALS is a multisystem disorder. In addition, there is in vivo evidence of axonal degeneration in the subcortical white matter in the motor region in patients with bulbar-onset ALS. This is consistent with a "dying back" process affecting cortical motoneurons in bulbar-onset ALS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:42:42