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Titolo:
Comparison of natural histories of progressive supranuclear palsy and multiple system atrophy
Autore:
Testa, D; Monza, D; Ferrarini, M; Soliveri, P; Girotti, R; Filippini, G;
Indirizzi:
C Besta Natl Neurol Inst, Dept Neurol, I-20133 Milan, Italy C Besta Natl Neurol Inst Milan Italy I-20133 eurol, I-20133 Milan, Italy C Besta Natl Neurol Inst, Dept Neuroepidemiol, Milan, Italy C Besta Natl Neurol Inst Milan Italy Dept Neuroepidemiol, Milan, Italy
Titolo Testata:
NEUROLOGICAL SCIENCES
fascicolo: 3, volume: 22, anno: 2001,
pagine: 247 - 251
SICI:
1590-1874(200106)22:3<247:CONHOP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RICHARDSON-OLSZEWSKI-SYNDROME; PARKINSONS-DISEASE; CLINICAL-FEATURES; DIAGNOSIS; CRITERIA;
Keywords:
multiple system atrophy; Parkinsonism; progressive supranuclear palsy; survival;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Girotti, R C Besta Natl Neurol Inst, Dept Neurol, Via Celoria 11, I-20133 Milan, Italy C Besta Natl Neurol Inst Via Celoria 11 Milan Italy I-20133 ly
Citazione:
D. Testa et al., "Comparison of natural histories of progressive supranuclear palsy and multiple system atrophy", NEUROL SCI, 22(3), 2001, pp. 247-251

Abstract

In order to identify early clinical features and survival predictors of supranuclear palsy (PSP) and multiple system atrophy (MSA), we compared the disease course of patients consecutively referred between 1987 and 1999 and followed to December 1999. Thirty-nine PSP and 74 MSA patients were diagnosed according to commonly accepted clinical criteria. Length of survival wasascertained from death certificates or by contacting relatives. Ten-year survival after disease onset was 29% for both disorders. Median survival was7.0 years (PSP) and 7.5 (MSA). Neither age, symptoms at onset, or disability at diagnosis predicted survival. At diagnosis, all PSP patients had oculomotor palsy, whereas 89% of MSA patients had dysautonomia; bradykinesia and falls were the most frequent common signs. Distinctive early signs were palilalia, cognitive impairment and hyperreflexia in PSP; hypophonia, anterocollis and dysautonomia in MSA. MSA patients responded better to levodopa. Attention to early distinctive features can improve differential diagnosis and inform subsequent management.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 22:59:58