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Titolo:
Modification of cortical excitability induced by gabapentin: a study by transcranial magnetic stimulation
Autore:
Rizzo, V; Quartarone, A; Bagnato, S; Battaglia, F; Majorana, G; Girlanda, P;
Indirizzi:
Univ Messina, Dept Neurosci Psychiat & Anaesthesiol Sci, I-98125 Messina, Italy Univ Messina Messina Italy I-98125 esthesiol Sci, I-98125 Messina, Italy
Titolo Testata:
NEUROLOGICAL SCIENCES
fascicolo: 3, volume: 22, anno: 2001,
pagine: 229 - 232
SICI:
1590-1874(200106)22:3<229:MOCEIB>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MOTOR CORTEX; CULTURED RODENT NEURONS; INHIBITION; DRUGS; BRAIN; ACID;
Keywords:
transcranial magnetic stimulation; cortical excitability; gabapentin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Rizzo, V Univ Messina, Dept Neurosci Psychiat & Anaesthesiol Sci, Via Consolare Valeria, I-98125 Messina, Italy Univ Messina Via Consolare Valeria Messina Italy I-98125 , Italy
Citazione:
V. Rizzo et al., "Modification of cortical excitability induced by gabapentin: a study by transcranial magnetic stimulation", NEUROL SCI, 22(3), 2001, pp. 229-232

Abstract

Transcranial magnetic stimulation (TMS) was employed before and after a single dose of gabapentin to evaluate how this drug affects the activity of excitatory and inhibitory circuits within the motor cortex. Eleven healthy volunteers were studied. For the evaluation of cortical excitability, the following parameters were taken into account: resting and active motor threshold (RMT, AMT); cortical silent period (CSP); and intracortical. inhibition(ICI) and facilitation (ICF). Peripheral silent period (PSP) was also detected. All parameters were measured before and 3 and 24 hours after 800 mg gabapentin was administered in a single oral dose. Gabapentin deepened the ICI and suppressed the ICF at 3 h but not at 5 h after dosing. We conclude that, in the normal human brain, gabapentin may act on intracortical excitability by shifting the balance towards less excitation and more inhibition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 23:47:13