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Titolo:
Do gap junctions couple interstitial cells of Cajal pacing and neurotransmission to gastrointestinal smooth muscle?
Autore:
Daniel, EE; Thomas, J; Ramnarain, M; Bowes, TJ; Jury, J;
Indirizzi:
McMaster Univ, Hlth Sci Ctr, Hamilton, ON L8N 3Z5, Canada McMaster Univ Hamilton ON Canada L8N 3Z5 tr, Hamilton, ON L8N 3Z5, Canada
Titolo Testata:
NEUROGASTROENTEROLOGY AND MOTILITY
fascicolo: 4, volume: 13, anno: 2001,
pagine: 297 - 307
SICI:
1350-1925(200108)13:4<297:DGJCIC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERCELLULAR CALCIUM WAVES; ENDOTHELIUM-DEPENDENT RELAXATION; RABBIT MESENTERIC-ARTERY; CANINE DISTAL ESOPHAGUS; GLYCYRRHETINIC ACID; CIRCULAR MUSCLE; INHIBITORY NEUROTRANSMISSION; EPITHELIAL-CELLS; PROXIMAL COLON; NITRIC-OXIDE;
Keywords:
electrical coupling; interstitial cells of Cajal networks; myogenic activity; neuro-transmission; slow waves;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Daniel, EE McMaster Univ, Hlth Sci Ctr, 1200 Main St W, Hamilton, ON L8N 3Z5, Canada McMaster Univ 1200 Main St W Hamilton ON Canada L8N 3Z5 Canada
Citazione:
E.E. Daniel et al., "Do gap junctions couple interstitial cells of Cajal pacing and neurotransmission to gastrointestinal smooth muscle?", NEUROG MOT, 13(4), 2001, pp. 297-307

Abstract

Interstitial cells of Cajal (ICC) pace gastrointestinal phasic activity and transmit nerve activity. Gap junctions may couple these cells to smooth muscle, but no functional evidence exists. The objective of this study was to use uncouplers of gap junctions, 18 alpha -glycyrrhetenic acid and its water-soluble analogue. carbonoxolone, to evaluate if gap junctions function in pacing and neurotransmission, After inhibition of nerve function with tetrodotoxin (TTX) and NG-nitro-L-arginine. (L-NOARG), ionomycin- or carbachol-initiated regular phasic activities of circular muscle strips from caninecolon and ileum, In some cases, the primary ICC network responsible for pacing was removed. The effects of inhibitors of gap junction conductance (10(-5)-10(-4) mol L-1) on frequencies and amplitudes of contraction were compared to appropriate time controls. Lower oesophageal sphincter (LOS) relaxations to nerve stimulation were studied before and after inhibition of gap junction functions. No major changes in LOS relaxations or frequencies of colonic or ileal contractions occurred, but amplitudes of contractions decreased from these agents. Similar results were obtained when the myenteric plexus-ICC network of ileum was removed. Regular phasic activity was not obtained after removal of the colon submuscular plexus ICC. These findings suggest that mechanisms other than gap junctions couple gut pacemaking activityand nerve transmission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 15:13:49