Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Estradiol and para-chlorophenylalanine downregulate the expression of brain aromatase and estrogen receptor-alpha mRNA during the critical period of feminization in tilapia (Oreochromis mossambicus)
Autore:
Tsai, CL; Wang, LH; Fang, LS;
Indirizzi:
Natl Sun Yat Sen Univ, Dept Marine Resources, Kaohsiung 80424, Taiwan NatlSun Yat Sen Univ Kaohsiung Taiwan 80424 es, Kaohsiung 80424, Taiwan Natl Museum Marine Biol & Aquarium, Pingtung, Taiwan Natl Museum Marine Biol & Aquarium Pingtung Taiwan um, Pingtung, Taiwan
Titolo Testata:
NEUROENDOCRINOLOGY
fascicolo: 5, volume: 74, anno: 2001,
pagine: 325 - 334
SICI:
0028-3835(200111)74:5<325:EAPDTE>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TROUT ONCORHYNCHUS-MYKISS; BETA MESSENGER-RNA; SEX-DIFFERENTIATION; GONADAL-STEROIDS; HYPOTHALAMIC AROMATASE; MOUSE HYPOTHALAMUS; PREOPTIC REGION; CHICKEN EMBRYOS; SEROTONIN; TEMPERATURE;
Keywords:
aromatase; gonadal steroids; gonadal steroid receptors; serotonin; sex differentiation; molecular neuroendocrinology; fish;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Tsai, CL Natl Sun Yat Sen Univ, Dept Marine Resources, Kaohsiung 80424, Taiwan Natl Sun Yat Sen Univ Kaohsiung Taiwan 80424 iung 80424, Taiwan
Citazione:
C.L. Tsai et al., "Estradiol and para-chlorophenylalanine downregulate the expression of brain aromatase and estrogen receptor-alpha mRNA during the critical period of feminization in tilapia (Oreochromis mossambicus)", NEUROENDOCR, 74(5), 2001, pp. 325-334

Abstract

The period of maximal feminizing action of 17 beta -estradiol (E-2) upon sex ratio is before 10 days posthatching in tilapia (Oreochromis mossambicus). The effect of E-2 at this time is mimicked by para-chlorophenylalanine (p-CPA), a serotonin (5-hydroxytryptamine; 5-HT) synthesis inhibitor. The effect of E-2 on sexual differentiation may be mediated by the 5-HT system, which is consistent with the suggestion in mammals. The masculinizing actions of 17 alpha -methyltestosterone (MT) are most potent later at up to day 20 of age, and may depend on MT induction of aromatase activity. In the present study, the effects of gonadal steroids and p-CPA on brain aromatase andestrogen receptor (ER) mRNA expression during the critical period of sexual differentiation were investigated. Treatment of tilapia with E-2 resultedin a significant decrease in the expression of brain aromatase and ER alpha between days 0 and 10, but not subsequently. The effect of E-2 at this time can be mimicked by p-CPA. Treatment of tilapia with MT, by contrast, resulted in a significant increase in brain aromatase, ER alpha and ER beta mRNA expression when given between days 10 and 20. The downregulation of brain aromatase and ERa mRNA expression by E-2 before 10 days of age and, in turn, the upregulation of brain aromatase and ER alpha and ERP mRNA expression by MT at up to day 20 of age coincide with the period in which E-2 and MThave the maximal effect on gonadal feminization and masculinization, respectively. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 20:20:37