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Titolo:
Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdfl/Hdf2 complexes
Autore:
Chen, L; Trujillo, K; Ramos, W; Sung, P; Tomkinson, AE;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Mol Med, San Antonio, TX 78245 USA Univ Texas San Antonio TX USA 78245 pt Mol Med, San Antonio, TX 78245 USA Univ Texas, Hlth Sci Ctr, Inst Biotechnol, San Antonio, TX 78245 USA Univ Texas San Antonio TX USA 78245 Biotechnol, San Antonio, TX 78245 USA
Titolo Testata:
MOLECULAR CELL
fascicolo: 5, volume: 8, anno: 2001,
pagine: 1105 - 1115
SICI:
1097-2765(200111)8:5<1105:PODDEB>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRAND BREAK REPAIR; DEPENDENT PROTEIN-KINASE; SACCHAROMYCES-CEREVISIAE; LIGASE-IV; HOMOLOGOUS RECOMBINATION; ATAXIA-TELANGIECTASIA; DAMAGE RESPONSE; KU PROTEIN; IN-VITRO; MRE11;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Tomkinson, AE Univ Texas, Hlth Sci Ctr, Dept Mol Med, 15355 Lambda Dr, SanAntonio, TX 78245 USA Univ Texas 15355 Lambda Dr San Antonio TX USA 78245 8245 USA
Citazione:
L. Chen et al., "Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdfl/Hdf2 complexes", MOL CELL, 8(5), 2001, pp. 1105-1115

Abstract

S. cerevisiae RAD50, MRE11, and XRS2 genes are required for telomere maintenance, cell cycle checkpoint signaling, meiotic recombination, and the efficient repair of DNA double-strand breaks (DSB)s by homologous recombination and nonhomologous end-joining (NHEJ). Here, we demonstrate that the complex formed by Rad50, Mre11, and Xrs2 proteins promotes intermolecular DNA joining by DNA ligase IV (Dnl4) and its associated protein Lif1. Our results show that the Rad50/Mre11/Xrs2 complex juxtaposes linear DNA molecules via their ends to form oligomers and interacts directly with Dnl4/Lif1. We alsodemonstrate that Rad50/Mre11/Xrs2-mediated intermolecular DNA joining is further stimulated by Hdf1/Hdf2, the yeast homolog of the mammalian Ku70/Ku80 heterodimer. These studies reveal specific functional interplay among theHdf1/Hdf2, Rad50/Mre11/Xrs2, and Dnl4/Lif1 complexes in NHEJ.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 08:45:45