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Titolo:
Blocking caspase-3-mediated proteolysis of IKK beta suppresses TNF-alpha-induced apoptosis
Autore:
Tang, GL; Yang, J; Minemoto, Y; Lin, AN;
Indirizzi:
Univ Chicago, Ben May Inst Canc Res, Comm Canc Biol, Chicago, IL 60637 USAUniv Chicago Chicago IL USA 60637 , Comm Canc Biol, Chicago, IL 60637 USA
Titolo Testata:
MOLECULAR CELL
fascicolo: 5, volume: 8, anno: 2001,
pagine: 1005 - 1016
SICI:
1097-2765(200111)8:5<1005:BCPOIB>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; SEVERE LIVER DEGENERATION; GAMMA-DEFICIENT MICE; INDUCED CELL-DEATH; KINASE COMPLEX; INCONTINENTIA PIGMENTI; ACTIVATION; INHIBITOR; CASPASE-8;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Lin, AN Univ Chicago, Ben May Inst Canc Res, Comm Canc Biol, 5841 S Maryland Ave,MC 6027, Chicago, IL 60637 USA Univ Chicago 5841 S Maryland Ave,MC 6027 Chicago IL USA 60637 USA
Citazione:
G.L. Tang et al., "Blocking caspase-3-mediated proteolysis of IKK beta suppresses TNF-alpha-induced apoptosis", MOL CELL, 8(5), 2001, pp. 1005-1016

Abstract

The transcription factor NF-kappaB is essential for survival of many cell types. However, cells can undergo apoptosis despite the concurrent NF-kappaB activation. It is unknown how the protection conveyed by NF-kappaB is overridden during apoptosis. We report here that I kappaB kinase (IKK) beta was specifically proteolyzed by Caspase-3-related caspases at aspartic acid residues 78, 242, 373, and 546 during tumor necrosis factor (TNF)alpha -induced apoptosis. Proteolysis of IKK beta eliminated its enzymatic activity, interfered with IKK activation, and promoted TNF-alpha killing. Point mutations that abrogate IKK beta proteolysis generated a caspase-resistant IKK beta mutant, which suppressed TNF-alpha -induced apoptosis. Thus, our study demonstrates that TNF-alpha -induced apoptosis requires caspase-mediated proteolysis of IKK beta.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:46:09