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Titolo:
Mild hypothermia increases Bcl-2 protein expression following global cerebral ischemia
Autore:
Zhang, ZJ; Sobel, RA; Cheng, DY; Steinberg, GK; Yenari, MA;
Indirizzi:
Stanford Univ, Sch Med, Dept Neurosurg, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 ept Neurosurg, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Palo Alto, CA 94304 USA Stanford Univ Palo Alto CA USA 94304 Neurol Sci, Palo Alto, CA 94304 USA Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA Stanford UnivStanford CA USA 94305 , Dept Pathol, Stanford, CA 94305 USA
Titolo Testata:
MOLECULAR BRAIN RESEARCH
fascicolo: 1-2, volume: 95, anno: 2001,
pagine: 75 - 85
SICI:
0169-328X(20011101)95:1-2<75:MHIBPE>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSIENT FOREBRAIN ISCHEMIA; NEURONAL DEATH; TRANSCRIPTION FACTORS; TRANSGENIC MICE; BRAIN INJURY; CYTOCHROME-C; IN-VIVO; APOPTOSIS; BAX; RAT;
Keywords:
apoptosis; Bcl-2; global cerebral ischemia; mild hypothermia; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Yenari, MA Stanford Univ, Sch Med, Dept Neurosurg, 1201 Welch Rd,MSLS Bldg,P304, Stanford, CA 94305 USA Stanford Univ 1201 Welch Rd,MSLS Bldg,P304 Stanford CA USA 94305
Citazione:
Z.J. Zhang et al., "Mild hypothermia increases Bcl-2 protein expression following global cerebral ischemia", MOL BRAIN R, 95(1-2), 2001, pp. 75-85

Abstract

Mild hypothermia protects the brain against experimental ischemia, but thereasons are not well known. We examined whether the protective effects of mild hypothermia could be correlated with alterations in expression of Bcl-2, an anti-apoptotic protein in a rat model of transient global ischemia. Following 10 min of forebrain ischemia, hippocampal neurons were examined 72h later for survival, expression of Bcl-2 family proteins and apoptosis. Intraischemic mild hypothermia was applied for 3 h (33 degreesC, isch-33) ornormal body temperature was maintained (37 degreesC, isch-37). Survival ofCAI neurons was significantly improved in the inch-33 group compared to the isch-37 group (90 vs. 53% survival; P <0.01). The proportion of Bcl-2-positive cells among surviving CAI neurons in the isch-33 group was increased compared to that of sham and isch-37 groups (P <0.01). Bax expression in CAI was no different between sham and isch-33 groups, but was significantly decreased in isch-37 (P <0.05). TUNEL staining was positive in many isch-37 CAI neurons, but absent in isch-33. Utilizing electron microscopy, more cells meeting criteria for apoptosis were observed in the isch-37 than isch-33. These data suggest that mild hypothermia attenuates apoptotic death, and that this protection may be related to increases in Bcl-2. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:52:33