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Titolo:
Analysis of the cell-dependent replication potentials of human immunodeficiency virus type 1 vif mutants
Autore:
Fujita, M; Sakurai, A; Doi, N; Miyaura, M; Yoshida, A; Sakai, K; Adachi, A;
Indirizzi:
Univ Tokushima, Sch Med, Dept Virol, Tokushima 7708503, Japan Univ Tokushima Tokushima Japan 7708503 t Virol, Tokushima 7708503, Japan Natl Inst Infect Dis, AIDS Res Ctr, Tokyo 2080011, Japan Natl Inst Infect Dis Tokyo Japan 2080011 S Res Ctr, Tokyo 2080011, Japan
Titolo Testata:
MICROBES AND INFECTION
fascicolo: 13, volume: 3, anno: 2001,
pagine: 1093 - 1099
SICI:
1286-4579(200111)3:13<1093:AOTCRP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRION INCORPORATION; MUTATIONAL ANALYSIS; VIRAL INFECTIVITY; RESTRICTIVE CELLS; PROTEIN; GENE; REQUIREMENT; GENERATION; NEF; ENHANCEMENT;
Keywords:
HIV-1; Vif; H9; VSV-G;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Fujita, M Univ Tokushima, Sch Med, Dept Virol, Tokushima 7708503, Japan Univ Tokushima Tokushima Japan 7708503 okushima 7708503, Japan
Citazione:
M. Fujita et al., "Analysis of the cell-dependent replication potentials of human immunodeficiency virus type 1 vif mutants", MICROBES IN, 3(13), 2001, pp. 1093-1099

Abstract

Eleven in-frame vif gene mutants of HIV type 1 produced in non-permissive cells were examined for their replication potentials in various CD4-positive and -negative cell lines. Virus replication for each mutant was monitoredby using several single- and multiple-cycle infectivity assays. Except fora mutant with wild-type phenotype, most mutants were severely defective for replication in all the cell lines as expected from the producer cell-dependent functioning of Vif so far reported. In contrast, two mutants, which have mutations in the hydrophilic or effector regions of Vif were found to have target cell-dependent replication potentials. These results demonstratethe presence of a novel category of the vif mutants important for elucidation of the Vif function. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

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Documento generato il 29/03/20 alle ore 08:59:22