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Titolo:
Assessment of frequency of progression to hypertension in nonhypertensive participants in the Framingham Heart Study: a cohort study
Autore:
Vasan, RS; Larson, MG; Leip, EP; Kannel, WB; Levy, D;
Indirizzi:
NHLBI, Framingham Heart Study, Framingham, MA 01702 USA NHLBI Framingham MA USA 01702 ngham Heart Study, Framingham, MA 01702 USA Boston Univ, Sch Med, Cardiol Sect, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 h Med, Cardiol Sect, Boston, MA 02118 USA Boston Univ, Sch Med, Dept Epidemiol & Prevent Med, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 emiol & Prevent Med, Boston, MA 02118 USA Harvard Univ, Sch Med, Beth Israel Hosp, Div Cardiol, Boston, MA USA Harvard Univ Boston MA USA Beth Israel Hosp, Div Cardiol, Boston, MA USA Harvard Univ, Sch Med, Beth Israel Hosp, Div Clin Epidemiol, Boston, MA USA Harvard Univ Boston MA USA rael Hosp, Div Clin Epidemiol, Boston, MA USA NHLBI, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892NHLBI, Bethesda, MD 20892 USA
Titolo Testata:
LANCET
fascicolo: 9294, volume: 358, anno: 2001,
pagine: 1682 - 1686
SICI:
0140-6736(20011117)358:9294<1682:AOFOPT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUTRITION EXAMINATION SURVEY; NORMAL BLOOD-PRESSURE; NATIONAL-HEALTH; UNITED-STATES; POPULATION; PREVALENCE; DISEASE; MEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Vasan, RS NHLBI, Framingham Heart Study, 5 Thurber St, Framingham, MA 01702 USA NHLBI 5 Thurber St Framingham MA USA 01702 mingham, MA 01702 USA
Citazione:
R.S. Vasan et al., "Assessment of frequency of progression to hypertension in nonhypertensive participants in the Framingham Heart Study: a cohort study", LANCET, 358(9294), 2001, pp. 1682-1686

Abstract

Background Patients with optimum (<120/80 mm Hg), normal (120-129/80-84 mmHg), and high normal (130-139/85-89 mm Hg) blood pressure (BP) may progress to hypertension (<greater than or equal to>140/90 mm Hg) over time. We aimed to establish the best frequency of BP screening by assessing the rates and determinants of progression to hypertension. Methods We assessed repeated BP measurements in individuals without hypertension (BP<140/90 mm Hg) from the Framingham Study (4200 men, 5645 women; mean age 52 years) who attended clinic examinations during 1978-94. The incidence of hypertension (or use of anti hypertensive treatment) and its determinants were studied. Findings A stepwise, increase in hypertension incidence occurred across the three non-hypertensive BP categories; 5.3% (95% CI 4.4-6.3%) of participants with optimum BP, 17.6% (15.2-20.3%) with normal, and 37.3% (33.3-41.5%)with high normal BP aged below age 65 years progressed to hypertension over 4 years. Corresponding 4-year rates of progression for patients 65 years and older were 16.0% (12.0-20.9), 25.5% (20.4-31.4), and 49.5% (42.6-56.4),respectively. Obesity and weight gain also contributed to progression; a 5% weight gain on follow-up was associated with 20-30% increased odds of hypertension. Interpretation High normal BP and normal BP frequently progress to hypertension over a period of 4 years, especially in older adults. These findings support recommendations for monitoring individuals with high normal BP oncea year, and monitoring those with normal BP every 2 years, and they emphasise the importance of weight control as a measure for primary prevention ofhypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:28:49