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Titolo:
Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons
Autore:
Reneman, L; Booij, J; de Bruin, K; Reitsma, JB; de Wolff, FA; Gunning, WB; den Heeten, GL; van den Brink, W;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Dept Nucl Med, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol & Biostat, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Human Toxicol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Child & Adolescent Psychiat, NL-1105 AZAmsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ AZAmsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Radiol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Psychiat, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Leiden Univ, Med Ctr, Toxicol Lab, Leiden, Netherlands Leiden Univ Leiden Netherlands ed Ctr, Toxicol Lab, Leiden, Netherlands
Titolo Testata:
LANCET
fascicolo: 9296, volume: 358, anno: 2001,
pagine: 1864 - 1869
SICI:
0140-6736(200112)358:9296<1864:EODSAL>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; BETA-CIT BINDING; IN-VIVO; DOPAMINE TRANSPORTERS; NONHUMAN-PRIMATES; PARTIAL RECOVERY; 52-WEEK PERIOD; NEUROTOXICITY; METHYLENEDIOXYMETHAMPHETAMINE; HUMANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Reneman, L Univ Amsterdam, Acad Med Ctr, Dept Nucl Med, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Meibergdreef 9 Amsterdam Netherlands NL-1105 AZ
Citazione:
L. Reneman et al., "Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons", LANCET, 358(9296), 2001, pp. 1864-1869

Abstract

Background 3,4-methylenedioxymethamphetamine (MDMA or ecstasy) is a popular recreational drug that has been shown to damage brain serotonin neurons in high doses. However, effects of moderate MDMA use on serotonin neurons have not been studied, and sex differences and the longterm effects of MDMA use on serotonin neurons have not been identified. We investigated the effects of moderate and heavy MDMA use, sex differences, and long-term effects of MDMA use on serotonin neurons in different brain regions. Methods By means of flyers posted in "rave" venues in Amsterdam, the Netherlands, we recruited 15 moderate MDMA users, 23 heavy MDMA users, 16 ex-MDMA users who had stopped using MDMA for more than 1 year, and 15 controls who claimed never to have used MDMA. We studied the effects of MDMA on brain serotonin neurons using (123)iodine-2 beta -carbomethoxy-3 beta-(4-iodophenyl) tropane ([I-123][beta -CIT)-a radioligand that binds with high affinityto serotonin transporters. Density of binding (expressed as a ratio of region-of-interest binding over binding in the cerebellum) was calculated by single-photon-emission computed tomography (SPELT). Findings We saw significant effects of group and group by sex (p=0.041 andp=0.022, respectively) on overall [I-123])beta -CIT binding ratios. In heavy MDMA users, significant decreases in overall binding ratios were seen inwomen (p<0.01) but not men (p=0.587). In female ex-MDMA users, overall densities of serotonin transporters were significantly higher than in heavy MDMA users (p=0.004), but not higher than in controls (p=0.524). Interpretation Our results indicate that heavy use of MDMA is associated with neurotoxic effects on serotonin neurons, that women might be more susceptible than men, and that MDMA-induced neurotoxic changes in several brain regions of female ex-MDMA users are reversible.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:47:28