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Titolo:
Transmission of hepatitis A through household contact
Autore:
Meyerhoff, AS; Jacobs, RJ;
Indirizzi:
Capitol Outcomes Res Inc, Alexandria, VA 22310 USA Capitol Outcomes Res Inc Alexandria VA USA 22310 Alexandria, VA 22310 USA
Titolo Testata:
JOURNAL OF VIRAL HEPATITIS
fascicolo: 6, volume: 8, anno: 2001,
pagine: 454 - 458
SICI:
1352-0504(200111)8:6<454:TOHATH>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMMUNITY-WIDE OUTBREAK; DAY-CARE-CENTERS; HOMOSEXUAL MEN; RISK-FACTORS; CHILDREN; INFECTION; EPIDEMIC; COST;
Keywords:
cost-benefit analysis; disease transmission; family characteristics; hepatitis A; vaccination;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Jacobs, RJ Capitol Outcomes Res Inc, 6188 Old Franconia Rd, Alexandria, VA22310 USA Capitol Outcomes Res Inc 6188 Old Franconia Rd Alexandria VA USA22310
Citazione:
A.S. Meyerhoff e R.J. Jacobs, "Transmission of hepatitis A through household contact", J VIRAL HEP, 8(6), 2001, pp. 454-458

Abstract

In the USA, cost effectiveness assessments support childhood hepatitis A vaccination in geographical areas with elevated disease rates, but not nationally. However, these studies do not address the reduction in disease transmission which may result from routine childhood vaccination. Using decisionanalysis, we estimated the number and age distribution of secondary hepatitis A cases occurring within households with an index case. Based on the age of the index case, we determined household size and age composition, the proportion of household members susceptible to hepatitis A, the probabilityof disease transmission, and the likelihood secondarily infected householdmembers would exhibit symptoms. Our model indicates that for every 100 index cases age 6-11 years, 47.2 secondary infections would occur within households, with 23.1 causing overt disease. Lower transmission rates for older index cases reflect smaller household sizes and a higher proportion of household contacts with hepatitis A immunity. When disease transmission rates are applied to a model simulating lifetime risks of hepatitis A, universal vaccination of an annual USA birth cohort is estimated to prevent 24100 cases of overt disease among household contacts in addition to 71000 cases among vaccinees. Sensitivity analysis provides a wide range of estimates, but even conservative assumptions suggest routine vaccination would yield an important reduction in secondary cases. Evaluations of hepatitis A prevention should consider the ability of immunization to protect household and other personal contacts.

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Documento generato il 01/12/20 alle ore 07:33:22