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Titolo:
Prediction of progressive liver fibrosis in hepatitis C infection by serumand tissue levels of transforming growth factor-beta
Autore:
Kanzler, S; Baumann, M; Schirmacher, P; Dries, V; Bayer, E; Gerken, G; Dienes, HP; Lohse, AW;
Indirizzi:
Univ Mainz, Dept Med 1, D-55131 Mainz, Germany Univ Mainz Mainz Germany D-55131 inz, Dept Med 1, D-55131 Mainz, Germany Univ Cologne, Dept Pathol, D-5000 Cologne, Germany Univ Cologne Cologne Germany D-5000 Dept Pathol, D-5000 Cologne, Germany Univ Essen Gesamthsch, Dept Gastroenterol, Essen, Germany Univ Essen Gesamthsch Essen Germany Dept Gastroenterol, Essen, Germany
Titolo Testata:
JOURNAL OF VIRAL HEPATITIS
fascicolo: 6, volume: 8, anno: 2001,
pagine: 430 - 437
SICI:
1352-0504(200111)8:6<430:POPLFI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-HISTORY; INTERFERON-ALPHA; GENE-EXPRESSION; TRANSGENIC MICE; SCORING SYSTEM; DISEASE; GROWTH-FACTOR-BETA-1; FACTOR-BETA-1; ASSOCIATION; CELLS;
Keywords:
cirrhosis; fibrogenesis; liver biopsy; prognosis; transforming growth factor-beta;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Lohse, AW Univ Mainz, Dept Med 1, Langenbeckstr 1, D-55131 Mainz, Germany Univ Mainz Langenbeckstr 1 Mainz Germany D-55131 Mainz, Germany
Citazione:
S. Kanzler et al., "Prediction of progressive liver fibrosis in hepatitis C infection by serumand tissue levels of transforming growth factor-beta", J VIRAL HEP, 8(6), 2001, pp. 430-437

Abstract

Although many patients with chronic viral hepatitis C infection suffer from progressive liver disease, the rate of fibrosis progression is highly variable and some patients do not show any measurable progression. However, our ability to predict which patients progress is very limited. Since transforming growth factor-beta (TGF-beta) is a key mediator of liver fibrogenesis, we assessed the predictive role of TGF-beta for fibrogenesis in chronic hepatitis C. We studied 39 patients with chronic hepatitis C in whom two liver biopsies were taken at least 12 months apart, and who did not receive therapy during this period. TGF-beta was measured by bioassay and by ELISA inserum samples taken at the time of the first biopsies, and TGF-beta was determined semiquantitatively by immunostaining of liver biopsy sections. Fibrosis was scored blinded in the biopsy samples by two pathologists independently. There was a close correlation between TGF-beta serum levels and the rate of fibrosis progression. Patients with no progression of fibrosis had significantly lower (59 ng/mL +/- 22) TGF-beta serum levels than patients with progressive disease (115 ng/mL +/- 20), and a TGF-beta level below 75 ng/mL was predictive for stable disease. Immunohistology for TGF-beta in biopsy samples was also predictive for progressive liver disease with fibrosisprogression found in those patients displaying staining of hepatocytes andsinusoidal cells. No such correlation was found with other markers such asprocollagen III peptide, viral load or transaminase levels. These results further support the role of TGF-beta in liver fibrogenesis, and offer an opportunity to predict clinical disease progression, which may help in selecting patients who are in need of therapeutic interventions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:49:27