Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Polychlorinated biphenyls in blood plasma among Swedish female fish consumers in relation to time to pregnancy
Autore:
Axmon, A; Rylander, L; Stromberg, U; Dyremark, E; Hagmar, L;
Indirizzi:
Univ Hosp, Inst Lab Med, Dept Occupat & Environm Med, SE-22185 Lund, Sweden Univ Hosp Lund Sweden SE-22185 pat & Environm Med, SE-22185 Lund, Sweden Stockholm Univ, Dept Analyt Chem, S-10691 Stockholm, Sweden Stockholm Univ Stockholm Sweden S-10691 Chem, S-10691 Stockholm, Sweden
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 6, volume: 64, anno: 2001,
pagine: 485 - 498
SICI:
1528-7394(20011123)64:6<485:PBIBPA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERSISTENT ORGANOCHLORINE COMPOUNDS; REPRODUCTIVE TOXICITY; CONTAMINATED CARP; RHESUS-MONKEYS; LAKE ONTARIO; TO-PREGNANCY; BIRTH-WEIGHT; BREAST-MILK; SAGINAW BAY; FATTY FISH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Axmon, A Univ Hosp, Inst Lab Med, Dept Occupat & Environm Med, SE-22185 Lund, Sweden Univ Hosp Lund Sweden SE-22185 ironm Med, SE-22185 Lund, Sweden
Citazione:
A. Axmon et al., "Polychlorinated biphenyls in blood plasma among Swedish female fish consumers in relation to time to pregnancy", J TOX E H A, 64(6), 2001, pp. 485-498

Abstract

The purpose of this study was to assess the association between 2,2',4,4,5,5'-hexachlorohiphenyl (CB-153) in plasma, a biomarker of exposure to polychlorinated biphenyls (PCB), and time to pregnancy TTP) in a group of women with a varying dietary exposure to PCB. For 121 Swedish east coast fishermen's wives (median year of birth 1956, range 1945-1968), information on self-reported TTP for the first planned pregnancy (median 2 mo, range 0-48) andCB-153 concentrations from blood samples drawn in 1995 (median 744 ng/g lipid, range 16-566) were available. Each woman's CB-153 concentration in plasma at the time immediately preceding her pregnancy was estimated, taking into account reduction of body burden of CB-153 due to lactation, the yearlyreduction of PCB in Baltic Sea fish, as well as the biological half-life of CB-153. Based on the estimated CB-153 concentrations, subjects were categorized into tertiles as low (37-206 ng/g lipid), medium (207-330 ng/g lipid), and high (331-1036 ng/g lipid) exposure groups. TTP in the medium- and high-exposure groups were then compared to TTP in the low-exposure group by estimating the corresponding success rate (i.e., the number of pregnancies per person month) ratios SuRR) using discrete Cox regression, taking into account essential confounders. No obvious association between estimated CB-153 concentration and TTP was observed (medium vs. low: SuRR 0.77 [95% Cl 0.47-1.28] and high vs. low: SuRR 0.95 [0.74-1.23]). The present data give nosupport for a negative association between the plasma CB-153 concentrations observed in the present study and TTP. It should, however, be borne in mind that the study group was rather small and mainly included relatively young women, likely to have been only moderately exposed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 04:16:13