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Titolo:
Absence of Delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice
Autore:
Zimmer, A; Valjent, E; Konig, M; Zimmer, AM; Robledo, P; Hahn, H; Valverde, O; Maldonado, R;
Indirizzi:
Univ Bonn, Psychiat Clin, D-53105 Bonn, Germany Univ Bonn Bonn Germany D-53105 onn, Psychiat Clin, D-53105 Bonn, Germany NIMH, Genet Lab, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892NIMH, Genet Lab, Bethesda, MD 20892 USA Univ Pompeu Fabra, Fac Ciencies Salut & Vida, Lab Neurofarmacol, Barcelona08003, Spain Univ Pompeu Fabra Barcelona Spain 08003 ofarmacol, Barcelona08003, Spain
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 23, volume: 21, anno: 2001,
pagine: 9499 - 9505
SICI:
0270-6474(200112)21:23<9499:AODDEI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED PLACE PREFERENCE; RECEPTOR MESSENGER-RNA; CANNABINOID-INDUCED ANTINOCICEPTION; MU-OPIOID RECEPTOR; RAT-BRAIN; KNOCKOUT MICE; ENDOGENOUS CANNABINOIDS; GENE-EXPRESSION; MORPHINE; LOCALIZATION;
Keywords:
cannabinoid; opioid; mice; mutation; withdrawal; addiction; place aversion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Zimmer, A Univ Bonn, Psychiat Clin, Mol Neurobiol Lab, Sigmund Freud Str 25, D-53125Bonn, Germany Univ Bonn Sigmund Freud Str 25 Bonn Germany D-53125 nn, Germany
Citazione:
A. Zimmer et al., "Absence of Delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice", J NEUROSC, 21(23), 2001, pp. 9499-9505

Abstract

The involvement of dynorphin on Delta -9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show specific changes in the behavioral effects of THC, including a reduction of spinal THC analgesia and the absence of THC-induced conditioned place aversion. In contrast, acute and chronic opioid effects were normal. The lack of negative motivational effects of THC in the absence of dynorphin demonstrates that this endogenous opioid peptide mediates the dysphoric effects of marijuana.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:00:41