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Titolo:
Functional interactions between tumor and peripheral nerve: Changes in excitability and morphology of primary afferent fibers in a murine model of cancer pain
Autore:
Cain, DM; Wacnik, PW; Turner, M; Wendelschafer-Crabb, G; Kennedy, WR; Wilcox, GL; Simone, DA;
Indirizzi:
Univ Minnesota, Dept Oral Sci, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 al Sci, Minneapolis, MN 55455 USA Univ Minnesota, Dept Pharmacol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 rmacol, Minneapolis, MN 55455 USA Univ Minnesota, Dept Neurol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 Neurol, Minneapolis, MN 55455 USA Univ Minnesota, Dept Neurosci, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 urosci, Minneapolis, MN 55455 USA Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 ychiat, Minneapolis, MN 55455 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 23, volume: 21, anno: 2001,
pagine: 9367 - 9376
SICI:
0270-6474(200112)21:23<9367:FIBTAP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIN-INDUCED NOCICEPTION; RAT SCIATIC-NERVE; SPINAL-CORD; GROWTH-FACTOR; SUBSTANCE-P; DIFFERENTIAL CONDUCTION; AXONAL BIFURCATIONS; SENSORY NEUROPATHY; MUSCLE AFFERENTS; SKIN BIOPSY;
Keywords:
tumor; cancer pain; primary afferent fibers; epidermal nerve fibers; murine model; hyperalgesia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Simone, DA Univ Minnesota, Dept Oral Sci, 17-252 Moos Tower,515 Delaware St SE, Minneapolis, MN 55455 USA Univ Minnesota 17-252 Moos Tower,515 Delaware St SE Minneapolis MN USA 55455
Citazione:
D.M. Cain et al., "Functional interactions between tumor and peripheral nerve: Changes in excitability and morphology of primary afferent fibers in a murine model of cancer pain", J NEUROSC, 21(23), 2001, pp. 9367-9376

Abstract

We used a murine model to investigate functional interactions between tumors and peripheral nerves that may contribute to pain associated with cancer. Implantation of fibrosarcoma cells in and around the calcaneus bone produced mechanical hyperalgesia of the ipsilateral paw. Electrophysiological recordings from primary afferent fibers in control and hyperalgesic mice withtumor revealed the development of spontaneous activity (0.2-3.4 Hz) in 34%of cutaneous C-fibers adjacent to the tumor (9-17 d after implantation). C-fibers in tumor-bearing mice exhibited a mean decrease in heat threshold of 3.5 +/- 0.10 degreesC. We also examined innervation of the skin overlyingthe tumor. Epidermal nerve fibers (ENFs) were immunostained for protein gene product 9.5, imaged using confocal microscopy, and analyzed in terms of number of fibers per millimeter of epidermal length and branching (number of nodes per fiber). Divergent morphological changes were linked to tumor progression. Although branching of ENFs increased significantly relative to control values, in later stages (16-24 d after implantation) of tumor growtha sharp decrease in the number of ENFs was observed. This decay of epidermal innervation of skin over the tumor coincided temporally with gradual loss of electrophysiological activity in tumor-bearing mice. The development of spontaneous activity and sensitization to heat in C-fibers and increased innervation of cutaneous structures within the first 2 weeks of tumor growth suggest activation and sensitization of a proportion of C-fibers. The decrease in the number of ENFs observed in later stages of tumor development implicates neuropathic involvement in this model of cancer pain.

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Documento generato il 28/09/20 alle ore 23:55:29