Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Evaluation of neurotoxicity of TIQ and MPTP and of parkinsonism-preventingeffect of 1-MeTIQ by in vivo measurement of pre-synaptic dopamine transporters and post-synaptic dopamine D-2 receptors in the mouse striatum
Autore:
Ishiwata, K; Koyanagi, Y; Abe, K; Kawamura, K; Taguchi, K; Saitoh, T; Toda, J; Senda, M; Sano, T;
Indirizzi:
Tokyo Metropolitan Inst Gerontol, Positron Med Ctr, Tokyo 1730022, Japan Tokyo Metropolitan Inst Gerontol Tokyo Japan 1730022 okyo 1730022, Japan Showa Pharmaceut Univ, Tokyo, Japan Showa Pharmaceut Univ Tokyo JapanShowa Pharmaceut Univ, Tokyo, Japan SHI Accelerator Serv Ltd, Tokyo, Japan SHI Accelerator Serv Ltd Tokyo Japan Accelerator Serv Ltd, Tokyo, Japan
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 4, volume: 79, anno: 2001,
pagine: 868 - 876
SICI:
0022-3042(200111)79:4<868:EONOTA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; TYROSINE-HYDROXYLASE; ENDOGENOUS AMINE; C-11 RACLOPRIDE; TREATED MICE; HUMAN-BRAIN; MONKEYS; DISEASE; BINDING; TETRAHYDROISOQUINOLINE;
Keywords:
dopamine transporter; 1-methyl-1,2,3,4-tetrahydroisoquinoline; MPTP; neuroprotection; parkinsonism; 1,2,3,4-tetrahydroisoquinoline;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Ishiwata, K Tokyo Metropolitan Inst Gerontol, Positron Med Ctr, 1-1 Naka Cho, Tokyo 1730022, Japan Tokyo Metropolitan Inst Gerontol 1-1 Naka Cho Tokyo Japan 1730022
Citazione:
K. Ishiwata et al., "Evaluation of neurotoxicity of TIQ and MPTP and of parkinsonism-preventingeffect of 1-MeTIQ by in vivo measurement of pre-synaptic dopamine transporters and post-synaptic dopamine D-2 receptors in the mouse striatum", J NEUROCHEM, 79(4), 2001, pp. 868-876

Abstract

Parkinson ism-inducing neurotoxicity of 1,2,3,4-tetrahydroisoquinoline (TIQ), as contrasted to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), and parkinsonism-preventing effect of 1-methyl-1;2,3,4-tetrahydroisoquinoline (1-MeTIQ) have been investigated in mice by measuring their effects on the in vivo binding of radioligand to pre-synaptic dopamine transporters (DATs) or to dopamine D-2 receptors (D2R) in the striatum. A significant reduction of the ligand-DATs binding was found in the mice treated with MPTP, butnot with TIQ, under the dosage inducing behavioral abnormality and loss oftyrosine hydroxylase-positive cells in the substantia nigra. A slight decrease in the ligand-DATs binding was observed in the mice given a larger dose of TIQ. Compensatory up-regulation in the post-synaptic D2Rs was found inthe MPTP-treated mice. Pre-treatment with (S)-enantiomer, but not (R)-enantiomer, of 1-MeTIQ prevented the degeneration of DATs to some extent. We concluded that the TIQ-induced parkinsonism model is different from the MPTP-induced model as evaluated by the radioligand-DATs binding and that (S)-1-MeTIQ has a preventing effect for the degeneration of the DATs to a certain extent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:18:21