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Titolo:
Selective age-related changes in the PKC-sensitive, calmodulin-binding protein, neurogranin, in the mouse brain
Autore:
Mons, N; Enderlin, V; Jaffard, R; Higueret, P;
Indirizzi:
Univ Bordeaux 1, CNRS, UMR 5106, Cognit Neurosci Lab, F-33405 Talence, France Univ Bordeaux 1 Talence France F-33405 osci Lab, F-33405 Talence, France Univ Bordeaux 1, Lab Nutr & Signalisat Cellulaire, INRA, USC, F-33405 Talence, France Univ Bordeaux 1 Talence France F-33405 NRA, USC, F-33405 Talence, France
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 4, volume: 79, anno: 2001,
pagine: 859 - 867
SICI:
0022-3042(200111)79:4<859:SACITP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
KINASE-C SUBSTRATE; LONG-TERM POTENTIATION; RC3/NEUROGRANIN MESSENGER-RNA; NITRIC-OXIDE SYNTHASE; RAT-BRAIN; THYROID-HORMONE; IMMUNOCYTOCHEMICAL LOCALIZATION; DEPENDENT REGULATION; SYNAPTIC PLASTICITY; SLEEP-DEPRIVATION;
Keywords:
ageing; hippocampus; immunohistochemistry; messenger RNA; neurogranin; plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Mons, N Univ Bordeaux 1, CNRS, UMR 5106, Cognit Neurosci Lab, Ave Fac, F-33405 Talence, France Univ Bordeaux 1 Ave Fac Talence France F-33405 05 Talence, France
Citazione:
N. Mons et al., "Selective age-related changes in the PKC-sensitive, calmodulin-binding protein, neurogranin, in the mouse brain", J NEUROCHEM, 79(4), 2001, pp. 859-867

Abstract

Brain ageing is associated with a dysregulation of intracellular calcium (Ca2+) homeostasis which leads to deficits in Ca2+-dependent signalling pathways and altered neuronal functions. Given the crucial role of neurogranin/RC3 (Ng) in the post-synaptic regulation of Ca2+ and calmodulin levels, age-dependent changes in the levels of Ng mRNA and protein expression were analysed in 3, 12, 24 and 31-month-old mouse brains. Ageing produced significant decreases in Ng mRNA expression in the dorsal hippocampal subfields, retrosplenial and primary motor cortices, whereas no reliable changes were seen in any other cortical regions examined. Western blot indicated that Ng protein expression was also down-regulated in the ageing mouse brain. Analysis of Ng immunoreactivity in both hippocampal CA1 and retrosplenial areas indicated that Ng protein in aged mice decreased predominantly in the dendritic segments of pyramidal neurones. These data suggest that age-related changes of postsynaptic Ng in selected brain areas, and particularly in hippocampus, may contribute to altered Ca2+/calmodulin-signalling pathways and to region-specific impairments of synaptic plasticity and cognitive decline.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:12:27