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Titolo:
Endocrine inactive and gonadotroph adenomas: diagnosis and management
Autore:
Losa, M; Mortini, P; Barzaghi, R; Franzin, A; Giovanelli, M;
Indirizzi:
Univ Milan, IRCCS San Raffaele, Dept Neurosurg, I-20132 Milan, Italy Univ Milan Milan Italy I-20132 ele, Dept Neurosurg, I-20132 Milan, Italy
Titolo Testata:
JOURNAL OF NEURO-ONCOLOGY
fascicolo: 2, volume: 54, anno: 2001,
pagine: 167 - 177
SICI:
0167-594X(200109)54:2<167:EIAGAD>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONFUNCTIONING PITUITARY-ADENOMAS; FOLLICLE-STIMULATING-HORMONE; THYROTROPIN-RELEASING-HORMONE; TERM FOLLOW-UP; SOMATOSTATIN RECEPTOR SCINTIGRAPHY; POSITRON-EMISSION-TOMOGRAPHY; TUMOR SIZE RESPONSE; RADIATION-THERAPY; BETA-SUBUNIT; OVARIAN HYPERSTIMULATION;
Keywords:
pituitary neoplasm; pituitary surgery; radiotherapy; gonadotropins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Losa, M Univ Milan, IRCCS San Raffaele, Dept Neurosurg, Via Olgettina 60, I-20132 Milan, Italy Univ Milan Via Olgettina 60 Milan Italy I-20132 0132 Milan, Italy
Citazione:
M. Losa et al., "Endocrine inactive and gonadotroph adenomas: diagnosis and management", J NEURO-ONC, 54(2), 2001, pp. 167-177

Abstract

Endocrine inactive pituitary adenomas represent about one quarter of all pituitary tumors. By immunocytochemistry, most of these tumors are positive for intact gonadotropins and/or their subunits. Clinical presentation is usually secondary to mass effect symptoms, such as visual disturbances, headache, and hypopituitarism. Differential diagnosis is usually accomplished byneuroradiologic studies, even though in selected cases positron emission tomography and/or single photon emission tomography may aid to distinguish pituitary adenomas from other endocrine inactive lesions, such as meningiomas and craniopharyngiomas. Surgical management is usually considered the first choice treatment for patients with endocrine inactive pituitary adenomasbecause it is very effective in ameliorating symptoms of chiasmal compression and headache. Radical removal of the tumor, however, is difficult to obtain because of the frequent invasiveness into the cavernous sinus. Radiation therapy diminishes the likelihood of tumor recurrence, especially in patients with demonstrable tumor remnants after surgery. Medical therapy with dopaminergic drugs, somatostatin analogs, or gonadotropin-releasing hormoneagonists or antagonists causes mild reduction of tumor size in few patients and, therefore, seems to be of limited value in the therapeutic management of patients with endocrine inactive pituitary adenomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:00:17