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Titolo:
Molecular pathology of pituitary adenomas
Autore:
Lloyd, RV;
Indirizzi:
Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA Mayo Clin Rochester MN USA lin, Dept Lab Med & Pathol, Rochester, MN USA
Titolo Testata:
JOURNAL OF NEURO-ONCOLOGY
fascicolo: 2, volume: 54, anno: 2001,
pagine: 111 - 119
SICI:
0167-594X(200109)54:2<111:MPOPA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARATIVE GENOMIC HYBRIDIZATION; TRANSFORMING GENE PTTG; HUMAN ENDOCRINE TUMORS; G-PROTEIN ONCOGENES; GROWTH-FACTOR-BETA; P27(KIP1) EXPRESSION; RAS MUTATIONS; CELL-LINES; SOMATOTROPH ADENOMAS; INHIBITOR P27(KIP1);
Keywords:
pituitary; p27; p16; cyclin-dependent kinase inhibitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Lloyd, RV Mayo Clin, Lab Med & Pathol, 200 1st St SW, Rochester, MN 55905 USA Mayo Clin 200 1st St SW Rochester MN USA 55905 ter, MN 55905 USA
Citazione:
R.V. Lloyd, "Molecular pathology of pituitary adenomas", J NEURO-ONC, 54(2), 2001, pp. 111-119

Abstract

A great deal of knowledge about anterior pituitary development, the pathogenesis of pituitary tumor and pituitary tumor progression has accumulated during the past decade. The role of multiple genes and gene products in pituitary development and the relationship of these genes to postnatal pituitary function and pituitary tumor development are being actively explored. Recent studies indicate that genes important in pituitary development do not contribute to pituitary tumorigenesis. However, mutations and other genetic alterations in these genes often lead to pituitary hypofunction. Many oncogenes and tumor suppressor genes that contribute to pituitary tumorigenesis have been described. There is a growing body of evidence showing that cellular and molecular changes in cyclins and cyclin-dependent kinase inhibitors contribute to pituitary tumorigenesis. Finally, recent comparative genomic hybridization studies show that many more genes that are important in pituitary tumorigenesis and tumor progression have yet to bebreak discovered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 05:04:57