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Titolo:
MECHANISM OF GLUCOSE-TRANSPORT ACROSS THE HUMAN AND RAT PLACENTAL BARRIER - A REVIEW
Autore:
TAKATA K; HIRANO K;
Indirizzi:
GUNMA UNIV,INST MOL & CELLULAR REGULAT,LAB MOL & CELLULAR MORPHOL MAEBASHI GUMMA 371 JAPAN KYORIN UNIV,SCH MED,DEPT ANAT MITAKA TOKYO 181 JAPAN
Titolo Testata:
Microscopy research and technique
fascicolo: 1-2, volume: 38, anno: 1997,
pagine: 145 - 152
SICI:
1059-910X(1997)38:1-2<145:MOGATH>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROVILLOUS PLASMA-MEMBRANES; GAP JUNCTION; IMMUNOHISTOCHEMICAL LOCALIZATION; HEMOTRICHORIAL PLACENTA; SUGAR TRANSPORTERS; FETAL CAPILLARIES; INSULIN-RECEPTOR; EXPRESSION; PROTEIN; ULTRASTRUCTURE;
Keywords:
GLUCOSE TRANSPORTER GLUT1; GLUCOSE TRANSPORTER GLUT3; PLACENTAL BARRIER; GAP JUNCTION; HUMAN; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
K. Takata e K. Hirano, "MECHANISM OF GLUCOSE-TRANSPORT ACROSS THE HUMAN AND RAT PLACENTAL BARRIER - A REVIEW", Microscopy research and technique, 38(1-2), 1997, pp. 145-152

Abstract

Glucose is one of the most important substances transferred from the maternal blood to the fetal circulation in the placenta, and its transport across the cellular membranes is mediated by glucose transporters. Facilitated-diffusion glucose transporter GLUT1 is abundant in the placental barrier, as is the case in other blood-tissue barriers, whereGLUT1 is present at the critical plasma membranes of the barrier cells. In the human placenta, the microvillous apical and the basal plasmamembranes of the syncytiotrophoblast are rich in GLUT1, which molecule seems to be responsible for the transcellular transport of glucose across the placental barrier. In the rat placental labyrinth, two layers of syncytiotrophoblasts (termed syncytiotrophoblasts I and II from the maternal side) serve as a barrier. GLUT1 is abundant at the plasma membrane of syncytiotrophoblast I facing the maternal side, and the plasma membrane of syncytiotrophoblast II facing the fetal side. Numerous gap junctions, made of connexin 26, connect syncytiotrophoblasts I and II, comprising a channel for the transfer of glucose between them. GLUT1 in combination with the gap junction, therefore, seems to serve as the structural basis for the transport of glucose across the rat placental barrier. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:30:26