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Titolo:
Tumor-induced immune dysfunctions caused by myeloid suppressor cells
Autore:
Bronte, V; Serafini, P; Apolloni, E; Zanovello, P;
Indirizzi:
Azienda Osped, Oncol Sect, Dept Oncol & Surg Sci, I-35128 Padua, Italy Azienda Osped Padua Italy I-35128 Oncol & Surg Sci, I-35128 Padua, Italy
Titolo Testata:
JOURNAL OF IMMUNOTHERAPY
fascicolo: 6, volume: 24, anno: 2001,
pagine: 431 - 446
SICI:
1524-9557(200111/12)24:6<431:TIDCBM>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; ENDOTHELIAL GROWTH-FACTOR; LUNG-CARCINOMA TUMORS; NECROSIS-FACTOR-ALPHA; BONE-MARROW CELLS; TOTAL LYMPHOID IRRADIATION; MATURE DENDRITIC CELLS; CD4(+) T-CELLS; NITRIC-OXIDE; IN-VIVO;
Keywords:
myeloid cells; immunosuppression; cancer immunotherapy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
131
Recensione:
Indirizzi per estratti:
Indirizzo: Bronte, V Azienda Osped, Oncol Sect, Dept Oncol & Surg Sci, Via Gattamelata 64, I-35128 Padua, Italy Azienda Osped Via Gattamelata 64 Padua Italy I-35128 dua, Italy
Citazione:
V. Bronte et al., "Tumor-induced immune dysfunctions caused by myeloid suppressor cells", J IMMUNOTH, 24(6), 2001, pp. 431-446

Abstract

In the late 1970s, several findings suggested that accessory cells distinct from lymphocytes might suppress immune reactivity in tumor-bearing hosts. Studies in animal models and patients later confirmed that cells driven toact as dominant immune suppressors by growing cancers could subvert the immune system. These cells have also been termed natural suppressors, a functional definition connoting their ability to hamper various T- and B-lymphocyte responses without prior activation and independently from antigen and MHC restriction. These properties were attributed to distinct cell populations. The phenotypic discrepancies, together with the lack of antigen specificity, have generated serious restraints to research on tumor-induced suppression. Recent evidence indicates that suppressor cells are closely related to immature myeloid precursors and can be found in several situations that can exert adverse effects on the immunotherapy of cancer. The present review is an attempt to address the nature and properties of immature myeloid suppressors and their relationship to dendritic cells and macrophages, with the aim of clarifying the complex network of tumor-induced, negative regulators of the immune system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 15:45:33