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Titolo:
TCR beta chain influences but does not solely control autoreactivity of V alpha 14J281T cells
Autore:
Gui, M; Li, J; Wen, LJ; Hardy, RR; Hayakawa, K;
Indirizzi:
Fox Chase Canc Ctr, Philadelphia, PA 19111 USA Fox Chase Canc Ctr Philadelphia PA USA 19111 , Philadelphia, PA 19111 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 11, volume: 167, anno: 2001,
pagine: 6239 - 6246
SICI:
0022-1767(200112)167:11<6239:TBCIBD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-ALPHA-CHAIN; V(ALPHA)14 NKT CELLS; CLASS-I MOLECULES; CD4-8 T-CELLS; ANTIGEN PRESENTATION; POSITIVE SELECTION; MOUSE CD1; RECOGNITION; GLYCOLIPIDS; SUBSET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Hayakawa, K Fox Chase Canc Ctr, Reimann Bldg,7701 Burholme Ave, Philadelphia, PA 19111USA Fox Chase Canc Ctr Reimann Bldg,7701 Burholme Ave Philadelphia PA USA 19111
Citazione:
M. Gui et al., "TCR beta chain influences but does not solely control autoreactivity of V alpha 14J281T cells", J IMMUNOL, 167(11), 2001, pp. 6239-6246

Abstract

CD1d-dependent accumulation of ap T cells bearing a canonical V alpha 14J alpha 281 alpha -chain (V alpha 14(+) T cells) is thought to model positiveselection of lipid-specific T cells, based on their ability to recognize CD1d-presented self glycolipid(s). However, it has been difficult to demonstrate self ligand specificity in this system, as most Va14(+) T cells do notexhibit significant autoreactivity despite high reactivity to alpha -galactosylceramide presented by CD1d (alpha -GalCer/CD1d). To assess the role ofTCR beta chain in determining the alpha -GalCer/CD1d vs autoreactive specificity of V alpha 14(+) T cells, we conducted TCR alpha or TCR beta chain transduction experiments. In this study we demonstrate, by combining different TCR beta chains with the V alpha 14 alpha -chain in retrovirally transduced T cell lines, that the Va14 alpha -chain plays a primary role, necessary but not sufficient for imparting a-GalCer/CD1d recognition. beta -Chain usage alone is not the sole factor that controls the extent of autoreactivity in Va14(+) T cells, since transduction of TCR alpha beta chains from a high CD1d autoreactive Va14(+) T cell line conferred the alpha -GalCer/CD1d specificity without induction of autoreactivity. Thus, heterogeneity of Va14(+) T cell reactivity is due to both beta -chain diversity and control mechanism(s) beyond primary TCR structure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 11:50:32