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Titolo:
Thymidine-analog and multi-nucleoside resistance mutations are observed inboth zidovudine-naive and zidovudine-experienced subjects with viremia after treatment with stavudine-containing regimens
Autore:
Ross, L; Henry, K; Paar, D; Salvato, P; Shaefer, M; Fisher, R; Liao, QM; St Clair, M;
Indirizzi:
GlaxoSmithKline, Dept Clin Virol, Res Triangle Pk, NC 27709 USA GlaxoSmithKline Res Triangle Pk NC USA 27709 es Triangle Pk, NC 27709 USA Regions Hosp, St Paul, MN USA Regions Hosp St Paul MN USARegions Hosp, St Paul, MN USA UTMB, Dept Internal Med, Galveston, TX USA UTMB Galveston TX USAUTMB, Dept Internal Med, Galveston, TX USA Diversified Med Practice PA, Houston, TX USA Diversified Med Practice PA Houston TX USA Practice PA, Houston, TX USA
Titolo Testata:
JOURNAL OF HUMAN VIROLOGY
fascicolo: 4, volume: 4, anno: 2001,
pagine: 217 - 222
SICI:
1090-9508(200107/08)4:4<217:TAMRMA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-1 REVERSE-TRANSCRIPTASE; PATIENTS RECEIVING STAVUDINE; HIGH-LEVEL RESISTANCE; CONFERRING RESISTANCE; INSERTION MUTATIONS; COMBINATION THERAPY; PROLONGED THERAPY; PLUS DIDANOSINE; DRUG RESISTANCE;
Keywords:
d4T; stavudine; zidovudine; ZDV; mutations;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Ross, L GlaxoSmithKline, Dept Clin Virol, 5 Moore Dr, Res Triangle Pk, NC 27709 USA GlaxoSmithKline 5 Moore Dr Res Triangle Pk NC USA 27709 27709 USA
Citazione:
L. Ross et al., "Thymidine-analog and multi-nucleoside resistance mutations are observed inboth zidovudine-naive and zidovudine-experienced subjects with viremia after treatment with stavudine-containing regimens", J HUMAN VIR, 4(4), 2001, pp. 217-222

Abstract

Objective: The type and frequency of mutations in the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase coding region observed in virus from antiretroviral therapy (ART)-experienced, zidovudine (ZDV)-naive subjects receiving stavudine (d4T)-based therapies were compared with mutations observed in virus from ART-experienced subjects with previous ZDV exposure. Methods: Plasma HIV-1 RNA was isolated from 67 ART-experienced subjects. Reverse transcriptase mutations were assessed by sequencing polymerase chainreaction products. Results: Thirty-four subjects (51%.) were ZDV-experienced (Z(exp)) and 33 (49%) were ZDV-naive and d4T-experienced (d(exp)Z(naive)). Human immunodeficiency virus type 1 from 16 of 33 (48%) d(exp)Z(naive) subjects and from 16of 34 (47%) Z(exp) subjects had thymidine analog mutations (TAMs). Multinucleoside resistance (MNR) mutations were observed in virus from 5 of 33 (15%) d(exp)Z(naive) subjects and 3 of 34 (9%) Z(exp) subjects. At least one TAM or MNR mutation was identified in IS of 33 (55%) of the former and in 19of 34 (56%) of the latter group. Conclusions: These results confirm recent reports that TAMs and MNR mutations can arise in subjects receiving d4T-based therapy who are naive with respect to ZDV.

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Documento generato il 01/04/20 alle ore 01:46:42