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Titolo:
Epidemiology of shigellosis in Lagos, Nigeria: Trends in antimicrobial resistance
Autore:
Iwalokun, BA; Gbenle, GO; Smith, SI; Ogunledun, A; Akinsinde, KA; Omonigbehin, EA;
Indirizzi:
Univ Lagos, Coll Med, Dept Biochem, Lagos, Nigeria Univ Lagos Lagos Nigeria Lagos, Coll Med, Dept Biochem, Lagos, Nigeria Nigerian Inst Med Res, Div Genet, Lagos, Nigeria Nigerian Inst Med Res Lagos Nigeria Med Res, Div Genet, Lagos, Nigeria Ogun State Univ, Coll Hlth Sci, Med Microbiol & Histopathol Dept, Shagamu,Nigeria Ogun State Univ Shagamu Nigeria iol & Histopathol Dept, Shagamu,Nigeria
Titolo Testata:
JOURNAL OF HEALTH POPULATION AND NUTRITION
fascicolo: 3, volume: 19, anno: 2001,
pagine: 183 - 190
SICI:
1606-0997(200109)19:3<183:EOSILN>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
INCREASING FREQUENCY; NALIDIXIC-ACID; AMPICILLIN; INFECTIONS;
Keywords:
dysentery; bacillary; Shigella; Escherichia coli; drug resistance; microbial; antibiotic resistance; Nigeria;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Iwalokun, BA Univ Lagos, Coll Med, Dept Biochem, PMB 12003, Lagos, NigeriaUniv Lagos PMB 12003 Lagos Nigeria MB 12003, Lagos, Nigeria
Citazione:
B.A. Iwalokun et al., "Epidemiology of shigellosis in Lagos, Nigeria: Trends in antimicrobial resistance", J HEALTH PO, 19(3), 2001, pp. 183-190

Abstract

Antimicrobial susceptibility of Shigella spp. and Escherichia coli, isolated from diarrhoeal patients in Lagos, was studied from March 1999 to February 2000. Four hundred fifty-nine isolates were identified as shigellae (62)and E. coli (397). Shigella flexneri, S. dysenteriae, S. boydii, and S. sonnei accounted, respectively, for 51.6%, 17.7%, 17.7%, and 13% of the totalnumber of shigellae isolated. Eleven cases of shigellosis occurred in the age group of 0-9 years, 22 cases in the age group of 10-19 years, and 29 cases in the age group of greater than or equal to 20 years. Of the 397 E. coli isolates, 11 were enteropathogenic E. coli (EPEC), and 7 of these strains were isolated with shigellae from stools of patients aged 0-9 year(s) (71.4%) and 10-19 years (28.6%). Over 70% of the Shigella isolates were resistant to two or more drugs, including ampicillin and tetracycline. Twenty-onedistinct multidrug resistance patterns were observed in these isolates. During 1990-2000, resistance to ampicillin increased from 70% to 90%, co-trimoxazole from 77% to 85%, chloramphenicol from 71% to 77%, streptomycin from71% to 79%, and nalidixic acid from 0% to 11.3%. Resistance to tetracycline decreased from 89% to 79% but with MIC50 and MIC90 values outside the susceptible range. While resistance to ciprofloxacin and ofloxacin remained nil with MIC50 and MIC90 values of 0.008 and 0.0016 mug/mL respectively. The results of this study revealed the endemicity of shigellosis with S. flexneri as the predominant serogroup in Lagos. Children and young adults were ata higher risk of severe shigellosis. The results also suggest that ampicillin, tetracycline, co-trimoxazole, and streptomycin should not be used as the first-line drugs in the treatment of shigellosis. Nalidixic acid should still be selectively used for treatment, while ciprofloxacin and ofloxacin can be ideal alternatives.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/06/20 alle ore 13:38:50