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Titolo:
Effects of vitamin A supplementation during pregnancy and early lactation on body weight of South African HIV-infected women
Autore:
Kennedy-Oji, C; Coutsoudis, A; Kuhn, L; Pillay, K; Mburu, A; Stein, Z; Coovadia, H;
Indirizzi:
Columbia Univ, Joseph L Mailman Sch Publ Hlth, Div Epidemiol, New York, NY10032 USA Columbia Univ New York NY USA 10032 Div Epidemiol, New York, NY10032 USA Univ Natal, Dept Pediat & Child Hlth, ZA-4001 Durban, South Africa Univ Natal Durban South Africa ZA-4001 lth, ZA-4001 Durban, South Africa
Titolo Testata:
JOURNAL OF HEALTH POPULATION AND NUTRITION
fascicolo: 3, volume: 19, anno: 2001,
pagine: 167 - 176
SICI:
1606-0997(200109)19:3<167:EOVASD>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; A-DEFICIENCY; TYPE-1 INFECTION; TRANSMISSION; CHILDREN; IRON; NUTRITION; MORTALITY; SERUM;
Keywords:
vitamin A; vitamin A deficiency; body weight; HIV; HIV infections; pregnancy; lactation; weight gain; nutrition; randomized controlled trials; double-blind method; South Africa;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Kennedy-Oji, C Columbia Univ, Joseph L Mailman Sch Publ Hlth, Div Epidemiol, 600 W 168th St, New York, NY 10032 USA Columbia Univ 600 W 168th St New York NY USA 10032 0032 USA
Citazione:
C. Kennedy-Oji et al., "Effects of vitamin A supplementation during pregnancy and early lactation on body weight of South African HIV-infected women", J HEALTH PO, 19(3), 2001, pp. 167-176

Abstract

Effects of vitamin A supplementation during pregnancy and early lactation on maternal weight among HIV-1-seropositive South African women were examined. Three hundred twelve HIV-seropositive pregnant women between 28 and 32 weeks gestation were studied as part of a randomized, double-blind, placebo-controlled trial at the King Edward VIII Hospital in Durban, South Africa. Patients were randomized to receive placebo or 5,000 IU of retinyl palmitate and 30 mg of beta-carotene daily during pregnancy. At delivery, patientsreceived placebo or 200,000 IU of retinyl palmitate. The main outcome measures were prenatal and postnatal maternal weight and weight loss at three months after delivery as measured in body mass index (BMI). Supplementation of vitamin A was not associated with improvements in prepartum weight gain but was significantly associated with improved weight retention three to six months after delivery (p=0.02). The benefit of vitamin A supplementation appeared to be confined to subgroups with baseline CD4+ count <200 cells/<mu>L and serum retinol 0-20 mug/dL. Similar trends were observed in maintenance of postpartum BMI. However, no statistically significant associations were observed. Although there was no benefit of vitamin A supplementation onprepartum weight gain, a benefit on maintenance of postnatal weight was observed. The benefit was highest among those who were vitamin A-deficient orwhose CD4+ count was <200 cells/<mu>L presupplementation. In populations for whom antiretroviral therapy is not readily available or accessible, the finding that vitamin A may improve postpartum weight lends some hope to a relatively inexpensive treatment which could be used for helping ameliorate some weight loss which is common during HIV infection.

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Documento generato il 25/01/20 alle ore 18:36:03