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Titolo:
The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptorantibody for sterile cure
Autore:
Belkaid, Y; Hoffmann, KF; Mendez, S; Kamhawi, S; Udey, MC; Wynn, TA; Sacks, DL;
Indirizzi:
NIAID, Parasit Dis Lab, Bethesda, MD 20892 USA NIAID Bethesda MD USA 20892 IAID, Parasit Dis Lab, Bethesda, MD 20892 USA NCI, Dermatol Branch, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 I, Dermatol Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 10, volume: 194, anno: 2001,
pagine: 1497 - 1506
SICI:
0022-1007(20011119)194:10<1497:TROI(I>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL CLONES; AZAR DERMAL LEISHMANIASIS; NITRIC-OXIDE SYNTHASE; HUMAN DENDRITIC CELLS; CUTANEOUS LEISHMANIASIS; INTERFERON-GAMMA; IMMUNE-RESPONSES; ACTIVATED MACROPHAGES; LATENT LEISHMANIASIS; MONOCLONAL-ANTIBODY;
Keywords:
Leishmania major; IL-10; skin; chronic infection; CD8(+) T cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Sacks, DL NIAID, Parasit Dis Lab, Bldg 4,Rm 126,Ctr Dr MSC 0425, Bethesda,MD 20892 USA NIAID Bldg 4,Rm 126,Ctr Dr MSC 0425 Bethesda MD USA 20892 92 USA
Citazione:
Y. Belkaid et al., "The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptorantibody for sterile cure", J EXP MED, 194(10), 2001, pp. 1497-1506

Abstract

Some pathogens (e.g., Mycobacterium tuberculosis, Toxoplasma gondii, Leishmania spp) have been shown to persist in their host after clinical cure, establishing the risk of disease reactivation. We analyzed the conditions necessary for the long term maintenance of Leishmania major in genetically resistant C57BL/6 mice after spontaneous healing of their dermal lesions. Interleukin (IL)-10 was found to play an essential role in parasite persistenceas sterile cure was achieved in IL-10-deficient and IL-4/IL-10 double-deficient mice. The requirement for IL-10 in establishing latency associated with natural infection was confirmed in IL-10-deficient mice challenged by bite of infected sand flies. The host-parasite equilibrium was maintained by CD4(+) and CD8(+) T cells which were each able to release IL-10 or interferon (IFN)-gamma, and were found to accumulate in chronic sites of infection,including the skin and draining lymph node. A high frequency of the dermalCD4(+) T cells released both IL-10 and IFN-gamma. Wild-type mice treated transiently during the chronic phase with anti-IL-10 receptor antibodies achieved sterile cure, suggesting a novel therapeutic approach to eliminate latency, infection reservoirs, and the risk of reactivation disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 10:24:33