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Titolo:
Separation methods applicable to prostate cancer diagnosis and monitoring therapy
Autore:
Sumi, S; Arai, K; Yoshida, K;
Indirizzi:
Dokkyo Univ, Sch Med, Dept Urol, Mibu, Tochigi 3210293, Japan Dokkyo UnivMibu Tochigi Japan 3210293 Urol, Mibu, Tochigi 3210293, Japan
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 764, anno: 2001,
pagine: 445 - 455
SICI:
1387-2273(20011125)764:1-2<445:SMATPC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
LECTIN AFFINITY-CHROMATOGRAPHY; HUMAN GLANDULAR KALLIKREIN-2; SUGAR-CHAIN STRUCTURES; HUMAN SEMINAL PLASMA; HUMAN HEPATOCELLULAR-CARCINOMA; ASN-LINKED OLIGOSACCHARIDES; GAMMA-GLUTAMYL-TRANSFERASE; METASTATIC TUMOR-CELLS; CONCANAVALIN-A; MOLECULAR-FORMS;
Keywords:
reviews; prostate-specific antigen;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
98
Recensione:
Indirizzi per estratti:
Indirizzo: Sumi, S Dokkyo Univ, Sch Med, Dept Urol, 880 Kitakobayashi, Mibu, Tochigi 3210293,Japan Dokkyo Univ 880 Kitakobayashi Mibu Tochigi Japan 3210293 293,Japan
Citazione:
S. Sumi et al., "Separation methods applicable to prostate cancer diagnosis and monitoring therapy", J CHROMAT B, 764(1-2), 2001, pp. 445-455

Abstract

During the last decade, significant research has been conducted using prostate-specific antigen (PSA) in the basic and clinical sciences and many advances have occurred in the clinical use of PSA for detecting and monitoringprostate cancer (PCa). Separation methods including gel-permeation chromatography, isoelectric focusing lectin-affinity chromatography, polyacrylamide gel electrophoresis and high-performance liquid chromatography have made significant contributions to the discovery and identification of different molecular forms of PSA. Furthermore, the measurement of free and total PSA has improved the ability of PSA to detect early PCa. However, unnecessary biopsies are still needed for men with slightly elevated PSA values. On the other hand, PSA is not adequate for staging newly diagnosed PCa and prognosticating the course in individual cases. The possible application of separation methods in the basic science of prostate cancer may be associated withidentification of more cancer-specific forms of PSA and discoveries of other serum proteins useful not only for detecting, but also for staging and prognosticating PCa. Such novel markers might lead to a better understandingof PCa aggressiveness and to developments in the clinical field of treatment. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:53:34