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Titolo:
Separation methods for antiviral phosphorus-containing drugs
Autore:
Ba, BB; Saux, MC;
Indirizzi:
Univ Bordeaux 2, Lab Pharmacocinet & Pharm Clin, Fac Pharm, F-33076 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33076 Pharm, F-33076 Bordeaux, France
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 764, anno: 2001,
pagine: 349 - 362
SICI:
1387-2273(20011125)764:1-2<349:SMFAPD>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; PERFORMANCE LIQUID-CHROMATOGRAPHY; SODIUM-CHLORIDE INJECTION; POST-COLUMN REACTION; CYTOMEGALOVIRUS RETINITIS; AIDS PATIENTS; PHOSPHONOFORMATE FOSCARNET; CEREBROSPINAL-FLUID; PHARMACOKINETICS; CIDOFOVIR;
Keywords:
reviews; foscarnet; cidofovir;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Ba, BB Univ Bordeaux 2, Lab Pharmacocinet & Pharm Clin, Fac Pharm, Zone Nord,Batiment 1A,146 Rue Leo Saignat, F-33076 Bordeaux, France Univ Bordeaux 2 Zone Nord,Batiment 1A,146 Rue Leo Saignat Bordeaux France F-33076
Citazione:
B.B. Ba e M.C. Saux, "Separation methods for antiviral phosphorus-containing drugs", J CHROMAT B, 764(1-2), 2001, pp. 349-362

Abstract

Among antiviral drugs, phosphorus-containing compounds, foscarnet and cidofovir, present adverse effects including renal toxicity. Since their main therapeutic target is the treatment of CMV retinitis, which needs lifelong maintenance therapy, accurate analytical methods are required for drug monitoring. According to the high hydrophilic property of the two compounds, ionpair reversed-phase HPLC methods were proposed for their separation in drug formulations and biological samples. Their lack of UV absorption at wavelengths above 205 mn does not allow the use of this detection technique for biological fluids. Electrochemical detection methods (coulometry and amperometry) led to a quantification limit of 15 muM for foscarnet. Fluorescent derivatives obtained by modification of cidofovir cytosine nucleus with alpha -haloketones offered advantage over UV detection and allowed to reach a detection limit of 5 ng/ml, making possible investigations on the drug time-course in biological fluids. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:39:19