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Titolo:
Separation methods for nucleoside analogues used for treatment of HIV-1 infection
Autore:
Pereira, AS; Tidwell, RR;
Indirizzi:
Univ N Carolina, Sch Med, Dept Pathol & Lab Med, Chapel Hill, NC 27599 USAUniv N Carolina Chapel Hill NC USA 27599 b Med, Chapel Hill, NC 27599 USA
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 764, anno: 2001,
pagine: 327 - 347
SICI:
1387-2273(20011125)764:1-2<327:SMFNAU>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; TANDEM MASS-SPECTROMETRY; BLOOD MONONUCLEAR-CELLS; HUMAN PLASMA; INTRACELLULAR ZIDOVUDINE; ULTRAVIOLET DETECTION; HUMAN SERUM; CARTRIDGE RADIOIMMUNOASSAY; QUANTITATIVE-DETERMINATION; MONKEY PLASMA;
Keywords:
reviews; nucleoside reverse transcriptase inhibitors;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Tidwell, RR Univ N Carolina, Sch Med, Dept Pathol & Lab Med, CB 7525, Chapel Hill, NC 27599 USA Univ N Carolina CB 7525 Chapel Hill NC USA 27599 NC 27599 USA
Citazione:
A.S. Pereira e R.R. Tidwell, "Separation methods for nucleoside analogues used for treatment of HIV-1 infection", J CHROMAT B, 764(1-2), 2001, pp. 327-347

Abstract

Clinicians design antiretroviral therapy to prevent HIV-1 replication and resistance, and researchers study antiretroviral concentrations to understand the pharmacokinetics of these drugs. Because drug efficacy and toxicity varies widely between patients receiving the same antiretroviral therapy, there is interest in monitoring individual patient concentrations of antiretroviral drugs. Good science and effective medical care demand inexpensive validated methods with high throughput that are capable of simultaneously analyzing multiple antiretroviral drugs in various matrices. Currently, protease inhibitors, non-nucleoside reverse transcriptase inhibitors, and nucleoside reverse transcriptase inhibitors are used to treat HIV-1 infection. This review summarizes published methods for the quantitation of nucleoside reverse transcriptase inhibitors and their metabolites in different matricesusing immunoassays, ultraviolet absorption, and mass spectrometry. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:49:01