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Titolo:
Separation methods for tricyclic antiviral drugs
Autore:
Suckow, RF;
Indirizzi:
New York State Psychiat Inst & Hosp, Analyt Psychopharmacol Lab, New York,NY 10032 USA New York State Psychiat Inst & Hosp New York NY USA 10032 rk,NY 10032 USA
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 764, anno: 2001,
pagine: 313 - 325
SICI:
1387-2273(20011125)764:1-2<313:SMFTAD>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-PLASMA; AMANTADINE HYDROCHLORIDE; AMINOADAMANTANE DERIVATIVES; RIMANTADINE HYDROCHLORIDE; PRECOLUMN DERIVATIZATION; FLUORESCENCE DETECTION; URINE; MEMANTINE; CHROMATOGRAPHY; METABOLITES;
Keywords:
reviews; amantadine; rimantadine; tromantadine; memantine;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Suckow, RF Nathan S Kline Inst Psychiat Res, 140 Old Orangeburg Rd, Orangeburg, NY 10962 USA Nathan S Kline Inst Psychiat Res 140 Old Orangeburg Rd Orangeburg NY USA 10962
Citazione:
R.F. Suckow, "Separation methods for tricyclic antiviral drugs", J CHROMAT B, 764(1-2), 2001, pp. 313-325

Abstract

A review of the published analytical methodology for the tricyclic antiviral (TAV) drugs is presented. While amantadine and rimantadine are the only two approved drugs for the prophylaxis and treatment of the influenza A virus, amantadine has also been approved for the treatment of Parkinson's disease. In addition, a few structurally related compounds are finding important clinical applications in other central nervous system-related disorders. To effectively evaluate the pharmacokinetics, biotransformations, stability, and other critical parameters that are necessary for pre-clinical and clinical studies, analytical methodology that conforms to the rigors of regulatory requirements must be developed and made available. This review discusses the analytical methods used in the determination of amantadine, rimantadine, tromantadine and memantine and the pre-clinical and clinical application of these techniques. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:20:04