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Titolo:
Separation methods for alkylating antineoplastic compounds
Autore:
Paci, A; Rieutord, A; Brion, F; Prognon, P;
Indirizzi:
Hop Robert Debre, Serv Pharm, F-75019 Paris, France Hop Robert Debre Paris France F-75019 Serv Pharm, F-75019 Paris, France Hop Robert Debre, Lab Tox Pharmacol, F-75019 Paris, France Hop Robert Debre Paris France F-75019 x Pharmacol, F-75019 Paris, France Fac Pharm Chatenay Malabry, Chim Analyt Lab, F-92296 Chatenay Malabry, France Fac Pharm Chatenay Malabry Chatenay Malabry France F-92296 labry, France
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 764, anno: 2001,
pagine: 255 - 287
SICI:
1387-2273(20011125)764:1-2<255:SMFAAC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; SOLID-PHASE EXTRACTION; TANDEM MASS-SPECTROMETRY; BONE-MARROW TRANSPLANTATION; ELECTRON-CAPTURE DETECTION; HUMAN-PLASMA; GAS-CHROMATOGRAPHY; FLUORESCENCE DETECTION; NITROGEN-PHOSPHORUS; HUMAN SERUM;
Keywords:
reviews; alkylating antineoplastic compounds;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
164
Recensione:
Indirizzi per estratti:
Indirizzo: Paci, A Hop Robert Debre, Serv Pharm, 48 Blvd Serurier, F-75019 Paris, France Hop Robert Debre 48 Blvd Serurier Paris France F-75019 is, France
Citazione:
A. Paci et al., "Separation methods for alkylating antineoplastic compounds", J CHROMAT B, 764(1-2), 2001, pp. 255-287

Abstract

The separating method for alkylating neoplastic compounds were reviewed based on the classification of the Merck Index (12th Edition). Each section, whenever available or relevant, was subdivided according to the following approach: stability studies, extraction methods, gas chromatography, high-performance liquid chromatography and capillary electrophoresis. At the end of each chapter a separate table summarizing the main characteristics of theseparating method were established. In particular LODs and/or LOQs were expressed as quantity to facilitate comparison between methods. This review highlights the problems to measure trace levels of these compounds into biological fluids with respect to their instability, adsorption to ass and plastic or derivatization requirements. Over the last decades, HPLC seems to bemore popular than GC for separating the alkylating agents. The developmentof narrow- or microbore LC coupled to MS is certainly the way to further improve both separation and sensitivity obtained in the different papers surveyed for this review. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/02/20 alle ore 19:43:43