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Titolo:
Separation of finasteride and analogues
Autore:
Macek, J;
Indirizzi:
Pharmakl Spol Sro, Lab & Clin Facil, CZ-16200 Prague 6, Czech Republic Pharmakl Spol Sro Prague Czech Republic 6 16200 Prague 6, Czech Republic
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 764, anno: 2001,
pagine: 207 - 215
SICI:
1387-2273(20011125)764:1-2<207:SOFAA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; TANDEM MASS-SPECTROMETRY; BENIGN PROSTATIC HYPERPLASIA; HUMAN PLASMA; 5-ALPHA-REDUCTASE INHIBITOR; STEROID 5-ALPHA-REDUCTASE; BIOLOGICAL-FLUIDS; PICOGRAM; EXTRACTION; SEMEN;
Keywords:
reviews; finasteride; epristeride; turosteride; 4-azasteroids;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Macek, J Pharmakl Spol Sro, Lab & Clin Facil, U Vojenske Nemocnice 1200, CZ-16200 Prague 6, Czech Republic Pharmakl Spol Sro U Vojenske Nemocnice 1200 Prague Czech Republic 6
Citazione:
J. Macek, "Separation of finasteride and analogues", J CHROMAT B, 764(1-2), 2001, pp. 207-215

Abstract

This review is focused on the different chromatographic strategies for determination of finasteride and its analogues in biological fluids. These compounds are used for the treatment of benign prostatic hyperplasia. Particular attention is paid to high-performance liquid chromatography with spectrophotometric and mass spectrometric detection, the clean-up procedures are also included. The relationships between pharmacokinetics of finasteride, dose administered and required limit of quantitation of the chromatographic assays are discussed. Tandem mass spectrometry is recommended as the detection method for measuring concentrations <1 ng/ml, while cheaper spectrophotometric detection may be selected for determination of higher concentrations. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 08:53:24