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Titolo:
Separation methods for anthraquinone related anti-cancer drugs
Autore:
Loadman, PM; Calabrese, CR;
Indirizzi:
Univ Bradford, Canc Res Unit, Bradford BD7 1DP, W Yorkshire, England Univ Bradford Bradford W Yorkshire England BD7 1DP , W Yorkshire, England Univ Newcastle Upon Tyne, Sch Med, Canc Res Unit, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England Univ Newcastle Upon Tyne Newcastle Upon Tyne Tyne & Wear England NE2 4HH
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 764, anno: 2001,
pagine: 193 - 206
SICI:
1387-2273(20011125)764:1-2<193:SMFARA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; SOLID-PHASE EXTRACTION; IMIDAZOACRIDINONE DERIVATIVES; IN-VIVO; CAPILLARY-ELECTROPHORESIS; PHARMACOKINETIC ANALYSIS; ANTINEOPLASTIC AGENTS; URINARY METABOLITES; MASS-SPECTROMETRY; ANTICANCER AGENTS;
Keywords:
reviews; anthracyclines; anthraquinone;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
83
Recensione:
Indirizzi per estratti:
Indirizzo: Loadman, PM Univ Bradford, Canc Res Unit, Bradford BD7 1DP, W Yorkshire, England Univ Bradford Bradford W Yorkshire England BD7 1DP e, England
Citazione:
P.M. Loadman e C.R. Calabrese, "Separation methods for anthraquinone related anti-cancer drugs", J CHROMAT B, 764(1-2), 2001, pp. 193-206

Abstract

The quinoid anthracycline-related anti-cancer agents represent an important group of anti-tumour drugs with a wide spectrum of activity. We review here some of the separation techniques used for the analysis of anthracyclines and related compounds. In this review we have covered a range of compounds from the early anthracycline antibiotics such as doxorubicin to the more recent anthracenediones and anthrapyrazoles such as mitoxantrone and losoxantrone, respectively. We also include novel compounds such as AQ4N and C1311, both awaiting clinical trial. Separations of the anthraquinone related anti-cancer agents are predominantly by HPLC. These separation techniques have been used for a variety of applications including drug stability, protein binding and therapeutic drug monitoring as well as detailed pharmacokinetic and metabolic studies. Pharmacokinetics, and therefore drug analysis, plays a central role in both the development of new agents and also leads to a better understanding of clinically established agents in this class. Sample preparation and extraction methods including solid-phase and liquid-liquid extraction have also been highlighted. Many anthraquinone related compounds are highly coloured and fluoresce. They are suitable for a range of detection methods including UV-Vis, electrochemical and fluorescence. The methods described are used for sometimes complex separations that are needed for the evaluation of such compounds in biological samples. (C) 2001 ElsevierScience B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:49:03