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Titolo:
Anthracyclines: recent developments in their separation and quantitation
Autore:
Zagotto, G; Gatto, B; Moro, S; Sissi, C; Palumbo, M;
Indirizzi:
Univ Padua, Dept Pharmaceut Sci, I-35131 Padua, Italy Univ Padua Padua Italy I-35131 Dept Pharmaceut Sci, I-35131 Padua, Italy
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 764, anno: 2001,
pagine: 161 - 171
SICI:
1387-2273(20011125)764:1-2<161:ARDITS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; N-(2-HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER-DOXORUBICIN; HUMAN PLASMA; CAPILLARY-ELECTROPHORESIS; FLUORESCENCE DETECTION; TOPOISOMERASE-II; RAT PLASMA; PHASE-I; METABOLITES; EPIRUBICIN;
Keywords:
reviews; anthracyclines; daunorubicin; doxorubicin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Zagotto, G Univ Padua, Dept Pharmaceut Sci, Via Marzolo 5, I-35131 Padua, Italy Univ Padua Via Marzolo 5 Padua Italy I-35131 5131 Padua, Italy
Citazione:
G. Zagotto et al., "Anthracyclines: recent developments in their separation and quantitation", J CHROMAT B, 764(1-2), 2001, pp. 161-171

Abstract

Anthracyclines are among the most widely used anticancer agents. Notwithstanding the large efforts to develop new drugs with a better pharmaceutical profile, daunorubicin, doxorubicin, epirubicin and idarubicin are still themost used in clinical practice. Many efforts are now ongoing to reduce theside effects by using pharmaceutical formulations able to release the drugin the most appropriate way and monitoring the quantity of anthracyclines and their metabolites in the body fluids or tissues frequently and in everypatient to maintain the drug concentration within the expected range. Thisreview describes the most recent developments in the separation and quantitation of the above clinically useful drugs, together with their principal metabolites. Some less widely used derivatives will also be considered. (C)2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:49:55