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Titolo:
Separation methods for camptothecin and related compounds
Autore:
Zufia, L; Aldaz, A; Giraldez, J;
Indirizzi:
Univ Hosp Navarra, Dept Pharm, Pamplona 31008, Spain Univ Hosp Navarra Pamplona Spain 31008 Dept Pharm, Pamplona 31008, Spain
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 764, anno: 2001,
pagine: 141 - 159
SICI:
1387-2273(20011125)764:1-2<141:SMFCAR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; DNA TOPOISOMERASE-I; ACTIVE METABOLITE SN-38; SOLID-PHASE EXTRACTION; PLUS CARBOXYLATE FORMS; EVERY 3 WEEKS; HUMAN PLASMA; FLUORESCENCE DETECTION; ANTITUMOR-ACTIVITY; IRINOTECAN CPT-11;
Keywords:
reviews; camptothecin; irinotecan; SN-38; topotecan; lurtotecan; DX 8951;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
163
Recensione:
Indirizzi per estratti:
Indirizzo: Aldaz, A Univ Hosp Navarra, Dept Pharm, C Pio XII S-N, Pamplona 31008, Spain Univ Hosp Navarra C Pio XII S-N Pamplona Spain 31008 1008, Spain
Citazione:
L. Zufia et al., "Separation methods for camptothecin and related compounds", J CHROMAT B, 764(1-2), 2001, pp. 141-159

Abstract

This paper reviews working procedures for the analytical determination of camptothecin and analogues. We give an overview of aspects such as the chemistry, structure-activity relationships, stability and mechanism of action of these antitumor compounds. The main body of the review describes separation techniques. Sample treatment and factors influencing high-performance liquid chromatography development are delineated. Published high-performanceliquid chromatographic methods are summarized to demonstrate the variability and versatility of separation techniques and a critical evaluation of separation efficiency, detection sensitivity and specificity of these methodsis reported. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:04:28