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Titolo:
Quantitation of camptothecin and related compounds
Autore:
Palumbo, M; Sissi, C; Gatto, B; Moro, S; Zagotto, G;
Indirizzi:
Univ Padua, Dept Pharmaceut Sci, I-35131 Padua, Italy Univ Padua Padua Italy I-35131 Dept Pharmaceut Sci, I-35131 Padua, Italy
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 764, anno: 2001,
pagine: 121 - 140
SICI:
1387-2273(20011125)764:1-2<121:QOCARC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; DNA TOPOISOMERASE-I; ACTIVE METABOLITE SN-38; PLUS CARBOXYLATE FORMS; PERFUSED RAT-LIVER; HUMAN PLASMA; FLUORESCENCE DETECTION; IRINOTECAN CPT-11; ANTITUMOR-ACTIVITY; UNBOUND 20(S)-CAMPTOTHECIN;
Keywords:
reviews; camptothecin; topotecan; irinotecan; lurtotecan; SN-38;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Palumbo, M Univ Padua, Dept Pharmaceut Sci, Via Marzolo 5, I-35131 Padua, Italy Univ Padua Via Marzolo 5 Padua Italy I-35131 5131 Padua, Italy
Citazione:
M. Palumbo et al., "Quantitation of camptothecin and related compounds", J CHROMAT B, 764(1-2), 2001, pp. 121-140

Abstract

Camptothecin and congeners represent a clinically very useful class of anticancer agents. Proper identification and quantitation of the original compounds and their metabolites in biological fluids is fundamental to assess drug metabolism and distribution in animals and in man. In this paper we will review the recent literature available on the methods used for separationand quantitative determination of the camptothecin family of drugs. Complications arise from the fact that they are chemically labile, and the pharmacologically active lactone structure can undergo ring opening at physiological conditions. In addition, a number of metabolic changes usually occur, producing a variety of active or inactive metabolites. Hence, the conditionsof extraction, pre-treatment and quantitative analysis are to be carefullycalibrated in order to provide meaningful results. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:04:11