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Titolo:
High-performance liquid chromatographic methods for the determination of topoisomerase II inhibitors
Autore:
Chen, CL; Thoen, KK; Uckun, FM;
Indirizzi:
Parker Hughes Inst, Parker Hughes Canc Ctr, Dept Oncol, St Paul, MN 55113 USA Parker Hughes Inst St Paul MN USA 55113 Dept Oncol, St Paul, MN 55113 USA Parker Hughes Inst, Parker Hughes Canc Ctr, Dept Chem, St Paul, MN 55113 USA Parker Hughes Inst St Paul MN USA 55113 Dept Chem, St Paul, MN 55113 USA Parker Hughes Inst, Parker Hughes Canc Ctr, Dept Pharmaceut Sci, St Paul, MN 55113 USA Parker Hughes Inst St Paul MN USA 55113 maceut Sci, St Paul, MN 55113 USA
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 764, anno: 2001,
pagine: 81 - 119
SICI:
1387-2273(20011125)764:1-2<81:HLCMFT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLID-PHASE EXTRACTION; DERIVATIVE DIMETHYLAMINOETOPOSIDE NK611; CARDIOPROTECTIVE AGENT DEXRAZOXANE; ELECTROSPRAY MASS-SPECTROMETRY; BREAST-CANCER CELLS; ELECTROCHEMICAL DETECTION; HUMAN-PLASMA; FLUORESCENCE DETECTION; ETOPOSIDE PHOSPHATE; BIOLOGICAL-FLUIDS;
Keywords:
reviews; topoisomerase II inhibitors; enzymes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
238
Recensione:
Indirizzi per estratti:
Indirizzo: Uckun, FM Parker Hughes Inst, Parker Hughes Canc Ctr, Dept Oncol, St Paul,MN 55113 USA Parker Hughes Inst St Paul MN USA 55113 , St Paul, MN 55113 USA
Citazione:
C.L. Chen et al., "High-performance liquid chromatographic methods for the determination of topoisomerase II inhibitors", J CHROMAT B, 764(1-2), 2001, pp. 81-119

Abstract

Various methods for separating eleven different types of topoisornerase II(TOPO-2) inhibitors, including epipodophyllotoxins, anthracyclines, anthracenediones, anthrapyrazoles, anthracenebishydrazones, indole derivatives, amino-acridines, benzisoquinolinediones, isoflavones, bisdioxopiperazines and thiobarbituric. acids, are summarized. Proper sample preparation and storage is critical to the successful analysis of some TOPO-2 inhibitors due todifficulties associated with adsorption, instability and complex biological components. Solid-phase and liquid-liquid extractions are widely used to separate TOPO-2 inhibitors from biological samples, although simple deproteinization followed by direct analysis of the supernatant is preferable to extraction based on its speed and simplicity. High-performance liquid chromatography (HPLC) is the favored method for the bioanalysis of TOPO-2 inhibitors. UV or diode array detection is generally employed for early pharmacokinetic studies, while fluorescence or electrochemical detection is used morefrequently for analytes with fluorescent or oxidative-reductive properties. For analyses requiring highly sensitive and/or specific detection, electrospray mass spectrometry (ESI-MS or ESI-MS-MS) provides a suitable alternative. A comprehensive compilation of the HPLC techniques currently used to separate TOPO-2 inhibitors will aid the future development of analytical methods for new TOPO-2 inhibitors. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:55:28