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Titolo:
Separation and identification methods for metalloproteinase inhibitors
Autore:
Peng, SX;
Indirizzi:
Procter & Gamble Co, Hlth Care Res Ctr, Mason, OH 45040 USA Procter & Gamble Co Mason OH USA 45040 Care Res Ctr, Mason, OH 45040 USA
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 764, anno: 2001,
pagine: 59 - 80
SICI:
1387-2273(20011125)764:1-2<59:SAIMFM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; MAGNETIC-RESONANCE SPECTROSCOPY; TANDEM MASS-SPECTROMETRY; SOLID-PHASE EXTRACTION; HUMAN LIVER-MICROSOMES; HPLC-NMR SPECTROSCOPY; OF-THE-ART; HUMAN PLASMA; MATRIX METALLOPROTEINASES; CAPILLARY-ELECTROPHORESIS;
Keywords:
reviews; metalloproteinase inhibitors;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Peng, SX Procter & Gamble Co, Hlth Care Res Ctr, 8700 Mason Montgomery Rd,Mason, OH 45040 USA Procter & Gamble Co 8700 Mason Montgomery Rd Mason OH USA 45040 A
Citazione:
S.X. Peng, "Separation and identification methods for metalloproteinase inhibitors", J CHROMAT B, 764(1-2), 2001, pp. 59-80

Abstract

Metalloproteinase inhibitors are being explored for the treatment of a wide variety of human diseases including cancers, arthritis, cardiovascular disorders, human immunodeficiency virus infection, and central nervous systemillnesses. This review provides an overview of various analytical sample preparation, separation, detection, and identification techniques employed for the quantitative and qualitative determination of these inhibitor compounds. Special emphasis is placed on biological sample preparation by automated solid-phase extraction, liquid-liquid extraction, and protein precipitation by centrifugation or filtration. Other sample preparation methodologiesare also evaluated. Applications of high-performance liquid chromatography, gas chromatography, and capillary electrophoresis to the quantitative determination of metalloproteinase inhibitors are described. Examples of qualitative analysis of metalloproteinase inhibitors by hyphenated liquid chromatography with mass spectrometry and nuclear magnetic resonance are also presented. The advantages and limitations of these separation and identification methodologies as well as other less frequently employed techniques are assessed and discussed. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:46:01