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Titolo:
Antitumor drugs possessing topoisomerase I inhibition: applicable separation methods
Autore:
Oguma, T;
Indirizzi:
Daiichi Pharmaceut Co Ltd, Drug Metab & Physicochem Property Res Lab, Egogawa Ku, Tokyo 1348630, Japan Daiichi Pharmaceut Co Ltd Tokyo Japan 1348630 a Ku, Tokyo 1348630, Japan
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 764, anno: 2001,
pagine: 49 - 58
SICI:
1387-2273(20011125)764:1-2<49:ADPTII>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; ACTIVE METABOLITE SN-38; CAMPTOTHECIN DERIVATIVE IRINOTECAN; SOLID-PHASE EXTRACTION; PLUS CARBOXYLATE FORMS; HUMAN PLASMA; FLUORESCENCE DETECTION; LACTONE FORM; SIMULTANEOUS QUANTITATION; RAT PLASMA;
Keywords:
reviews; topoisomerase I inhibitors; enzymes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Oguma, T Daiichi Pharmaceut Co Ltd, Drug Metab & Physicochem Property Res Lab, Egogawa Ku, 1-16-13 Kitakasai, Tokyo 1348630, Japan Daiichi PharmaceutCo Ltd 1-16-13 Kitakasai Tokyo Japan 1348630
Citazione:
T. Oguma, "Antitumor drugs possessing topoisomerase I inhibition: applicable separation methods", J CHROMAT B, 764(1-2), 2001, pp. 49-58

Abstract

Separation methods for antitumor drugs capable of topoisomerase I inhibition were reviewed in this study. Camptothecin (CPT) its related analogues seemed to be promising anticancer drugs that exhibit topoisomerase I inhibition. This group of compounds contain a closed alpha -hydroxy-delta -lactone ring (lactone form) that can undergo reversible hydrolysis to form the open-ring form (carboxylate form). In vitro pharmacological study showed that the antitumor activity of the lactone form was higher than that of the carboxylate form. Thus a quantitative method to separate these two forms is important to evaluate the pharmacokinetics and pharmacodynamics of these compounds. Nevertheless, current separation methods are complicated by the pH-dependent instability of the lactone moiety. High-performance liquid chromatography (HPLC) coupled with fluorometric detection has been widely used for the quantitation of the drug as the intact lactone form or as the total lactone carboxylate forms in biological matrices. In this report we reviewed current applicable chromatographic techniques for further bioanalytical. studies of CPT derivatives including sample preparations, HPLC columns, mobile phases and additives. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:12:13