Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Analytical approaches for traditional Chinese medicines exhibiting antineoplastic activity
Autore:
Tsai, TH;
Indirizzi:
Natl Res Inst Chinese Med, Taipei 112, Taiwan Natl Res Inst Chinese Med Taipei Taiwan 112 nese Med, Taipei 112, Taiwan Natl Yang Ming Univ, Inst Tradit Med, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 nst Tradit Med, Taipei 112, Taiwan
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 764, anno: 2001,
pagine: 27 - 48
SICI:
1387-2273(20011125)764:1-2<27:AAFTCM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; SOLID-PHASE EXTRACTION; IONIZATION MASS-SPECTROMETRY; CAMPTOTHECIN DERIVATIVE IRINOTECAN; PLUS CARBOXYLATE FORMS; LC-MS METHOD; HUMAN PLASMA; FLUORESCENCE DETECTION; BIOLOGICAL-FLUIDS; METABOLITE SN-38;
Keywords:
reviews; Chinese antineoplastic compounds;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
188
Recensione:
Indirizzi per estratti:
Indirizzo: Tsai, TH Natl Res Inst Chinese Med, Taipei 112, Taiwan Natl Res Inst Chinese Med Taipei Taiwan 112 Taipei 112, Taiwan
Citazione:
T.H. Tsai, "Analytical approaches for traditional Chinese medicines exhibiting antineoplastic activity", J CHROMAT B, 764(1-2), 2001, pp. 27-48

Abstract

Traditional Chinese medicines have attracted great interest in recent researchers as alternative antineoplastic therapies. This review focuses on analytical approaches to various aspects of the antineoplastic ingredients of traditional Chinese medicines. Emphasis will be put on the processes of biological sample extraction, separation, clean-up steps and the detection. The problems of the extraction solvent selection and different types of column chromatography are also discussed. The instruments considered are gas chromatography, capillary electrophoresis (CE) and high-performance liquid chromatography (HPLC) connected with various detectors (ultraviolet, fluorescence, electrochemistry, mass, etc.). In addition, determinations of antineoplastic, herbal ingredients, including camptothecin, taxol (paclitaxel), vinblastine, vincristine, podophyllotoxin, colchicine, and their related compounds, such as irinotecan, SN-38, topotecan, 9-aminocamptothecin, docetaxel (taxotere) and etoposide, are briefly summarized. These drugs are structurally based on the herbal ingredients, and some of them are in trials for clinical use. Evaluation of potential antineoplastic herbal ingredients, such as harringtonine, berberine, emodin, genistein, berbamine, daphnoretin, andirisquinone, are currently investigated in laboratories. Other folk medicines are excluded from this paper because their antineoplastic ingredients are unknown. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:37:02