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Titolo:
Quantitative analysis of fentanyl in rat plasma by gas chromatography withnitrogen-phosphorus detection
Autore:
Choi, HS; Shin, HC; Khang, G; Rhee, JM; Lee, HB;
Indirizzi:
Korea Res Inst Chem Technol, Biomat Lab, Taejon 305606, South Korea Korea Res Inst Chem Technol Taejon South Korea 305606 05606, South Korea Chonbuk Natl Univ, Dept Polymer Sci & Technol, Chonju 561756, South Korea Chonbuk Natl Univ Chonju South Korea 561756 , Chonju 561756, South Korea Korea Res Inst Chem Technol, Toxicol Res Ctr, Pharmacokinet & Toxicokinet Lab, Taejon 305606, South Korea Korea Res Inst Chem Technol Taejon South Korea 305606 05606, South Korea
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1, volume: 765, anno: 2001,
pagine: 63 - 69
SICI:
1387-2273(200112)765:1<63:QAOFIR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID-CHROMATOGRAPHY; MASS-SPECTROMETRY; IMMUNOASSAY DETECTION; ALFENTANIL; BLOOD; PHARMACOKINETICS; ASSAY; METABOLITES; CONGENERS; HORSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, HB Korea Res Inst Chem Technol, Biomat Lab, POB 107, Taejon 305606, South Korea Korea Res Inst Chem Technol POB 107 Taejon South Korea 305606 rea
Citazione:
H.S. Choi et al., "Quantitative analysis of fentanyl in rat plasma by gas chromatography withnitrogen-phosphorus detection", J CHROMAT B, 765(1), 2001, pp. 63-69

Abstract

A sensitive assay method was developed to determine fentanyl, an opiate agonist, in rat plasma by gas chromatography with nitrogen-phosphorus detection. For the pretreatment of plasma samples, sodium hydroxide was added to denature protein and n-butyl chloride was used to extract fentanyl. The calibration curve was linear within the concentration range 0.5 to 50 ng/ml (r=0.9997). The limit of detection was 0.1 ng/ml, and 0.5 ng/ml could be quantified with acceptable precision. Furthermore, fentanyl could be determined in only 200 mul of rat plasma. The method has been successfully applied to an intramuscular pharmacokinetic study at a dose of 10 mug/kg. Therefore, the current method is a valuable analytical tool for investigating the pharmacokinetics of fentanyl at low clinical doses. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:46:52