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Titolo:
Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, andthe testes
Autore:
Abe, Y; Matsumoto, S; Wei, SM; Nezu, K; Miyoshi, A; Kito, K; Ueda, N; Shigemoto, K; Hitsumoto, Y; Nikawa, J;
Indirizzi:
Ehime Univ, Sch Med, Dept Pathol & Hyg 1, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Shigenobu, Ehime 7910295, Japan Okayama Univ, Fac Sci, Dept Biol Chem, Div Clin Immunol, Okayama 7000005, Japan Okayama Univ Okayama Japan 7000005 Clin Immunol, Okayama 7000005, Japan Kyushu Inst Technol, Fac Comp Sci & Syst Engn, Dept Biochem Engn & Sci, Kawazu, Fukuoka 8208502, Japan Kyushu Inst Technol Kawazu Fukuoka Japan 8208502 , Fukuoka 8208502, Japan
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 47, volume: 276, anno: 2001,
pagine: 44003 - 44011
SICI:
0021-9258(20011123)276:47<44003:CACOAP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED KILLER-CELLS; SACCHAROMYCES-CEREVISIAE; KILLING ACTIVITY; TYROSINE KINASE; NUCLEAR IMPORT; DNA-DAMAGE; LAK CELLS; LYMPHOTOXIN; GENE; P53;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Abe, Y Ehime Univ, Sch Med, Dept Pathol & Hyg 1, Shigenobu, Ehime 7910295,Japan Ehime Univ Shigenobu Ehime Japan 7910295 obu, Ehime 7910295, Japan
Citazione:
Y. Abe et al., "Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, andthe testes", J BIOL CHEM, 276(47), 2001, pp. 44003-44011

Abstract

A human protein kinase, p53-related protein kinase (PRPK), was cloned froman interleukin-2-activated cytotoxic T-cell subtraction library. PRPK appears to be a homologue of a growth-related yeast serine/threonine protein kinase, YGR262c. However, a complementation assay using YGR262c-disrupted yeast indicated that PRPK is not functionally identical to the yeast enzyme. PRPK expression was observed in interleukin-2-activated cytotoxic T-cells, some human epithelial tumor cell lines, and the testes. The intrinsic transcriptional activity of p53 was up-regulated by a transient transfection of PRPK to COS-7 cells. PRPK was shown to bind to p53 and to phosphorylate p53 at Ser-15. These results indicate that PRPK may play an important role in the cell cycle and cell apoptosis through phosphorylation of p53.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:28:42